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News
The latest news, updates and announcements from the Nuffield Department of Medicine.
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Lymphocyte Activation Gene (LAG)-3 Is Associated With Mucosal Inflammation and Disease Activity in Ulcerative Colitis
Abstract Background and Aims Lymphocyte activation gene [LAG]-3 is an immune checkpoint and its expression identifies recently activated lymphocytes that may ...
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Relevance of RIBA-3 supplementary test to HCV PCR positivity and genotypes for HCV confirmation of blood donors.
HCV antibody screening of 624,910 blood donations resulted in 3,832 samples being referred for confirmation. All were tested by RIBA-3 with 2,710 negative, 945 ...
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Third-generation recombinant immunoblot assay: comparison of reactivities according to hepatitis C virus genotype.
BACKGROUND: Recombinant immunoblot assay (RIBA) is widely used as a supplemental test in hepatitis C virus (HCV) confirmatory algorithms. As this assay is ...
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A versatile synthesis of 3-substituted 4-cyano-1,2,3,4-tetrahydro-1-oxo- β-carbolines
In a project aimed at the synthesis of analogues of the cytotoxic -carboline alkaloid bauerine C with more advantageous solubility properties, a 3-amino ...
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Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.
Tissue inhibitor of metalloproteinase 3 (TIMP-3) is an important regulator of extracellular matrix (ECM) turnover. TIMP-3 binds to sulfated ECM ...