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The ferrocene analogue 4b had an IC50 = 4 nM (HDAC1), 180 nM (HDAC8) and was effective in a Xenopus model of tubulin deacetylation. Analogue 4a displayed mainly μM IC50 values against HDACs apart from HDAC6 (IC50 = 69 nM).

Original publication

DOI

10.1039/c1md00203a

Type

Journal article

Journal

MedChemComm

Publisher

Royal Society of Chemistry (RSC)

Publication Date

2012

Volume

3

Pages

61 - 64