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Artemisinin-type compounds are used for the treatment of uncomplicated and severe forms of malaria. They reduce parasitaemia more rapidly than any other antimalarial compound known, and are effective against multidrug-resistant parasites. However, uncertainties remain as to how they act on the parasite and cause toxicity. In this review, we summarize current ideas.

Original publication

DOI

10.1016/s1471-4922(00)01838-9

Type

Journal article

Journal

Trends in parasitology

Publication Date

03/2001

Volume

17

Pages

122 - 126

Addresses

UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases, CDS Cluster, 20, avenue Appia, CH-1211, Geneva, Switzerland. olliarop@who.ch

Keywords

Animals, Humans, Plasmodium falciparum, Malaria, Falciparum, Sesquiterpenes, Artemisinins, Antimalarials