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Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moiety of haemoglobin. The production of dose‐dependent methaemoglobinaemia by 8‐aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent Plasmodium vivax and Plasmodium ovale malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8‐aminoquinoline drug and dose optimization.

Original publication

DOI

10.1111/bcp.15219

Type

Journal article

Journal

British Journal of Clinical Pharmacology

Publisher

Wiley

Publication Date

06/2022

Volume

88

Pages

2657 - 2664