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1. Almitrine at a dose of 0·5 mg h−1 kg−1 given intravenously over 2 h had no effect on resting ventilation in normal males. 2. There was a small, but insignificant, rise in the hypercapnic drive to breathe as compared with placebo. 3. A large rise in the hypoxic drive to breathe was seen in response to almitrine. 4. These findings support the claim that almitrine has its action on ventilation via the peripheral chemoreceptors. 5. No correlation between blood levels of almitrine and the rise in hypoxic response was seen.

Original publication

DOI

10.1042/cs0630401

Type

Journal article

Journal

Clinical Science

Publisher

Portland Press Ltd.

Publication Date

01/10/1982

Volume

63

Pages

401 - 404