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1. Three non-major histocompatibility complex genes, Idd-3, Idd-4 and Idd-5, that influence the onset of autoimmune type 1 diabetes in the non-obese diabetic mouse have been located on chromosomes 3, 11 and 1. 2. In undertaking this study, a new map of the mouse genome has been created from polymerase chain reaction-analysable mouse microsatellite markers. 3. The homologues of these genes may reside on human chromosomes 1 or 4 (Idd-3), 17 (Idd-4) and 2q (Idd-5).

Type

Journal article

Journal

Clin Sci (Lond)

Publication Date

03/1993

Volume

84

Pages

257 - 262

Keywords

Animals, Chromosome Mapping, Diabetes Mellitus, Type 1, Disease Models, Animal, Disease Susceptibility, Genetic Linkage, Genetic Markers, Humans, Mice, Mice, Inbred NOD, Sequence Homology