Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Isoelectric focusing gel electrophoresis was used to look for variant HLA molecules in five patients with HLA-B27 negative ankylosing spondylitis (AS). The isoelectric points of the HLA-A and B antigens from these patients and HLA paired controls were identical. This implies that the HLA-A and B antigens from the patients with AS and the controls are similar. Gene conversion of a nucleotide sequence from a B27 positive gene is thus unlikely to be the explanation for the existence of AS in patients who are HLA-B27 negative by alloantisera typing.

Original publication

DOI

10.1136/ard.47.12.1001

Type

Journal article

Journal

Ann Rheum Dis

Publication Date

12/1988

Volume

47

Pages

1001 - 1003

Keywords

Female, Gene Conversion, HLA-A Antigens, HLA-B Antigens, HLA-B27 Antigen, Humans, Isoelectric Focusing, Male, Spondylitis, Ankylosing