The research in the Vivanco's laboratory focuses on the study of the human immune response to viral infections. We have been primarily focused on the study of a mosquito-borne human pathogen, Dengue virus. Also, we have begun to study two emerging pathogens in México, Chikungunya virus and Zika virus. The research projects are focused in studying about the host immune factors that modulate disease severity and correlates with protection or pathogenesis. Particularly, we are interested in studying the contribution of soluble molecules produced by different lymphocytes populations from both origins: from innate and adaptive immunity. Other important issues which are studied in the lab are the characterization of new adjuvants for vaccination and the development or validation of new diagnostic tests for different endemic pathogens. Recently, we have started to study the immunoregulatory role of endothelial cells in the context of viral infections.
Godoy-Lozano EE, Téllez-Sosa J, Sánchez-González G, Sámano-Sánchez H, Aguilar-Salgado A, Salinas-Rodríguez A, Cortina-Ceballos B, Vivanco-Cid H, Hernández-Flores K, Pfaff JM, Kahle KM, Doranz BJ, Gómez-Barreto RE, Valdovinos-Torres H, López-Martínez I, Rodriguez MH, Martínez-Barnetche J. Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response. Genome Med. 2016 Feb 25;8(1):23. doi: 10.1186/s13073-016-0276-1.
Vivanco-Cid H, Maldonado-Rentería MJ, Sánchez-Vargas LA, Izaguirre-Hernández IY, Hernández-Flores KG, Remes-Ruiz R. Dynamics of interleukin-21 production during the clinical course of primary and secondary dengue virus infections. Immunol Lett. 2014 Sep;161(1):89-95. doi: 10.1016/j.imlet.2014.05.006. Epub 2014 May 22.
Sánchez-Vargas LA, Sánchez-Marce EE, Vivanco-Cid H. Evaluation of the SD BIOLINE Dengue Duo rapid test in the course of acute and convalescent dengue infections in a Mexican endemic region. Diagn Microbiol Infect Dis. 2014 Apr;78(4):368-72. doi: 10.1016/j.diagmicrobio.2013.12.019. Epub 2014 Jan 7.
Ruiz-Pacheco JA, Vivanco-Cid H, Izaguirre-Hernández IY, Estrada-García I, Arriaga-Pizano L, Chacón-Salinas R, Fonseca-Coronado S, Vaughan G, Tovar KR, Rivera-Osorio MP, Escobar-Gutiérrez A. TREM-1 modulation during early stages of dengue virus infection. Immunol Lett. 2014 Mar-Apr;158(1-2):183-8. doi: 10.1016/j.imlet.2014.01.003. Epub 2014 Jan 18.