Prof Constantino III Roberto López Macías

Prof Constantino III Roberto López-Macías

Head of the Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI” of the Mexican Institute for Social Security (IMSS) and NDM Visiting Professor of Immunology. Lecturer at Faculty of Chemistry, National Autonomous University of Mexico (UNAM)

Collaborating with Prof Paul Klenerman, Sidney Truelove Professor of Gastroenterology, Chairman of the Peter Medawar Building for Pathogen Research, Experimental Medicine Division, University of Oxford, Group Head / PI and Consultant Physician.


Prof. López-Macías research is focused to study the mechanisms involved in the generation of long lasting Immunity and the application of this knowledge to develop new adjuvants and vaccines. He led the research that showed that VH replacement mechanism of receptor editing could contribute to the formation of protective antibodies during viral infections. His work has contributed obtain important knowledge about generation of immunity and to the development of vaccine candidates for Influenza, Typhoid Fever, Non-typhoidal Salmonellosis, as well as adjuvants using Salmonella outer membrane proteins and plant viruses as platforms. These vaccines and adjuvants have been or are in the process to be tested in clinical trials and have been protected by several patents. During the pandemic influenza outbreak in the year 2009 that had Mexico as epicentre, he directed different protocols to study outbreak patients, and was the Principal Investigator of a Phase 2 clinical trial of a novel virus like particle vaccine for pandemic Influenza A(H1N1)2009 in which 4550 subjects were enrolled. His work has also contributed to strength the national research infrastructure as co-founder and member of the board of directors of the Mexico Centre for Clinical Research (2011), whereas at IMSS, he is the co-founder of the Flow Cytometry Unit (2005) and Advance Microscopy Unit (2016).

Prof. López-Macías is a member of the Mexican National System of Researchers level 3 since 2017 (top national position), and member of the Mexican Translational Immunology Research Group of the Federation of Clinical Immunological Societies (FOCIS) Centres of Excellence (2018). He is actively enrolled in pre- and post- graduated curses of Immunology at UNAM and at the National School of Biological Sciences of the National Polytechnic Institute, in addition, mentors graduate and undergraduate students from the main Universities in Mexico. In 2012 was appointed as Visiting Professor of Immunology at the Nuffield Department of Medicine, University of Oxford and in 2017 became member of the Management Oversight Board of BactiVac network for bacterial vaccine development at University of Birmingham U.K. He was a member (2008-2012) of the IMSS National Research Commission (a prestigious national ethics committee) and is an international and national grant referee. Additionally, he is a reviewer of manuscripts for peer-reviewed international and national journals and guest editor of Frontiers in Immunology and Mediators of Inflammation. His work has received several prizes such as the Ferdinand Worthmann prize from the Swiss Society of Immunology and Allergology in 1999, National Pharmaceutical Chamber Prize (CANIFARMA): 1st place for Technological development in 2000 and in 2007. 1st place of the Mexican Foundation for Health-GLAXO Prize 2010, for Clinical Research. Prof. López-Macías is an active member of the Mexican Society of Immunology from which he served as President (2014-2016) and an active member of the Mexican Academy of Sciences since 2008 and the Mexican National Academy of Medicine (2016).


Selected Publications

2018. Perez-Shibayama et al, Fibroblastic reticular cells serve as primary immune checkpoint in visceral adipose tissues and secure peritoneal immunity. Science Immunology. 10;3(26). pii: eaar4539. doi: 10.1126/sciimmunol.aar4539.