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Constantino III Roberto López-Macías

Titular Researcher D (Professor) at the Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI” of the Mexican Institute for Social Security (IMSS) and NDM Visiting Professor of Immunology

 Collaborating with Prof Paul Klenerman, Professor of Immunology, Group Head / PI and Consultant Physician, Peter Medawar Building, Experimental Medicine Division, University of Oxford

Lecturer at Faculty of Chemistry, National Autonomous University of Mexico (UNAM).

Prof. López-Macías research is focused to study the mechanisms that translate Inflammation into long lasting Immunity and the application of this knowledge to develop new adjuvants and vaccines. This work has contributed obtain important knowledge about generation of immunity and to the development of vaccine candidates for Influenza, Typhoid Fever, Non-typhoidal Salmonellosis, as well as adjuvants using Salmonella outer membrane proteins and plant viruses as platforms. These vaccines and adjuvants have been or are in the process to be tested in clinical trials and have been protected by several patents. During the pandemic influenza outbreak in the year 2009 that had Mexico as epicentre, he directed different protocols to study outbreak patients, and was the Principal Investigator of a Phase 2 clinical trial of a novel virus like particle vaccine for pandemic Influenza A(H1N1)2009 in which 4550 subjects were enrolled. His work has also contributed to strength the national research infrastructure as co-founder and member of the board of directors of the Mexico Centre for Clinical Research (2011), whereas at IMSS, he is the co-founder and head of the Flow Cytometry Unit (2005).

Prof. López-Macías is actively enrolled in pre- and post- graduated curses of Immunology at UNAM and at the National School of Biological Sciences of the National Polytechnic Institute, in addition, mentors graduate and undergraduate students from the main Universities in Mexico. In 2012 was appointed as Visiting Professor of Immunology at the Nuffield Department of Medicine, University of Oxford. He was a member (2008-2012) of the IMSS National Research Commission (a prestigious national ethics committee), and is an international and national grant referee. Additionally, he is a reviewer of manuscripts for peer-reviewed international and national journals and guest editor of Frontiers in Immunology and Mediators of Inflammation. His work has received several prizes such as the Ferdinand Worthmann prize from the Swiss Society of Immunology and Allergology in 1999, National Pharmaceutical Chamber Prize (CANIFARMA): 1st place for Technological development in 2000 and in 2007. 1st place of the Mexican Foundation for Health-GLAXO Prize 2010, for Clinical Research. Prof. López-Macías is an active member of the Mexican Society of Immunology: Secretary-Treasurer (2004-2006), Vice-President (2012-2014) and President (2014-2016) and an active member of the Mexican Academy of Sciences since 2008.

Selected Publications

2011. López-Macías C., et al. Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico. Vaccine. 13;29(44):7826-34.

2010. MacLennan Calman, et al. Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults. Science. 328(5977):508-12.

2009. Cervantes-Barragán L., et al. TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens. European Journal of Immunology. 39(1):126-135.