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Eduardo Alves dos Santos

Former Member

Development of new vaccine candidates and challenge models for Plasmodium vivax

Eduardo Alves’s research involved the development and test new vaccines against human malaria (Plasmodium vivax) by encoding candidate genes in recombinant virus (AdChOX1 and MVA). The efficacy and immunogenicity of those virus vaccines are tested in rodent models which are challenge with transgenic rodent malaria (P. berghei) expressing human malaria (P. vivax) vaccine candidates. This project allows the screening of many vaccine candidates against P. vivax parasites in animal models.

Key publications

Alves E, Bartlett PJ, Garcia CR, Thomas AP. “Melatonin and IP3-induced Ca2+ release from intracellular stores in the malaria parasite Plasmodium falciparum within infected red blood cells.” J Biol Chem. 2011 Feb 18;286(7):5905-12. doi: 10.1074/jbc.M110.188474. Epub 2010 Dec 13.

Alves E, Iglesias BA, Deda DK, Budu A, Matias TA, Bueno VB, Maluf FV, Guido RV, Oliva G, Catalani LH, Araki K, Garcia CR. “Encapsulation of metalloporphyrins improves their capacity to block the viability of the human malaria parasite Plasmodium falciparum.” Nanomedicine. 2014 Nov 15. pii: S1549-9634(14)00550-4. doi: 10.1016/j.nano.2014.09.018.

Cruz LN, Alves E, Leal MT, Juliano MA, Rosenthal PJ, Juliano L, Garcia CR. “FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii.” Int J Parasitol. 2011 Mar; 41(3-4):363-72. doi: 10.1016/j.ijpara.2010.10.009. Epub 2010 Dec 17.