- Postdoctoral scientist in Neglected Tropical Diseases: P Vivax Malaria, Dengue and Chagas, Reyes-Sandoval Group
Dr Fabiana Leoratti works on P Vivax Malaria, Dengue and Chagas.
Malaria is one of the main global public health problems. The majority of malaria morbidity and mortality is caused by two of the five species of Plasmodium that infect humans, P. vivax and P. falciparum. The essential role for changing this situation would be the development of effective malaria vaccines. The rupture of erythrocytic schizonts induces clinical malaria of a systemic production of pro-inflammatory cytokines. For example, abundant pro-inflammatory cytokines production is associated with occurrence of cerebral malaria in humans and in mouse models, CD4+ T cells are responsible for control the parasitemia in this stage and modulating the immune response. The CD4+ T cells play a central role in the function of the immune system, firstly by helping B cells to produce antibodies. CD4+ T cells are fundamental for the generation of germinal centers (GCs), particularly a Th subset, T follicular helper (Tfh) cells. Tfh cells express the chemokine receptor 5 (CXCR5), which allows their migration into B cells follicles. Tfh cells secrete IL-4, IL-10 and IL-21 cytokines that induce growth. Our aims were understand the mechanisms involved between Tfh and Plasma B cells after vaccination with different viral-vectored approaches evaluating the efficacy and immunogenicity of the immune response.
Costa, Pedro AC; Leoratti, Fabiana MS; Figueiredo, Maria M; Tada, Mauro S; Pereira, Dhelio B; Junqueira, Caroline; Soares, Irene S; Barber, Daniel L; Gazzinelli Ricardo T; Antonelli, Lis RV. Induction of Inhibitory Receptors on T Cells During Plasmodium vivax Malaria Impairs Cytokine Production. The Journal of Infectious Diseases, v. 212, p. 1999-2010, 2015.
Antonelli, Lis RV; Leoratti, Fabiana MS; Costa, Pedro AC; Rocha, Bruno C; Diniz, Suelen Q; Tada, Mauro S; Pereira, Dhelio B; Teixeira-Carvalho, Andrea ; Golenbock, Douglas T; Gonçalves, Ricardo; Gazzinelli Ricardo T. The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria. PLoS Pathogens v. 10, p. e1004393, 2014.
Leoratti FMS; Trevelin, Silvia Cellone; Cunha, Fernando Queiroz; Rocha, Bruno Coelho; Costa, Pedro Augusto Carvalho; Gravina, Humberto Doriguêtto; Tada, Mauro Shugiro; Pereira, Dhelio Batista; Golenbock, Douglas Taylor; Antonelli, Lis RV; Gazzinelli Ricardo T; Rodrigues, Mauricio Martins . Neutrophil Paralysis in Plasmodium vivax Malaria. PLoS Neglected Tropical Diseases v. 6, p. e1710, 2012.