News — Nuffield Department of Medicine

New global study links pain and genetic basis of endometriosis

14 March 2023

Researchers at NDM’s Wellcome Centre for Human Genetics and Nuffield Department of Women’s & Reproductive Health, in collaboration with 25 teams across the world have found compelling genetic evidence linking endometriosis to other types of pain.

Combination therapy is found to be more effective on severe scrub typhus

2 March 2023

A team from Mahidol Oxford Tropical Medicine Research Unit (MORU) in Bangkok along with Prof Varghese and the INTREST trial investigators in India, finds the combination of antibiotics is significantly more effective than the current monotherapy.

Expectations for polygenic scores need to be realistic

1 March 2023

Testing a population for multiple genes at once will always be limited in its ability to accurately predict disease risk, experts are warning.

MORU study shows ivermectin not effective treatment against COVID

23 February 2023

Researchers at NDM's Mahidol Oxford Tropical Medicine Research Unit found that high doses of the drug ivermectin, controversially recommended by some high-profile political and media figures during the COVID-19 pandemic, are ineffective at treating the COVID-19 virus.

NHS COVID-19 app saved 10,000 lives

22 February 2023

A team of experts at NDM’s Pandemic Sciences Institute and the Department of Statistics at the University of Warwick estimate the NHS COVID-19 app prevented around 1 million cases, 44,000 hospitalisations and 9,600 deaths during its first year.

New research opens new strategies for cancer therapeutics

13 February 2023

Researchers from NDM’s Target Discovery Institute and CAMS Oxford Institute, and the Department of Biochemistry uncovered at the molecular level how protein BIRC6 (a giant ubiquitin ligase) keeps cells alive.

New genetic mutation linked to rare conditions

30 January 2023

Researchers from Wellcome Centre for Human Genetics at the Nuffield Department of Medicine, have discovered that a rare type of genetic variant can be responsible for two well-known skeletal disorders.

Essential research by COI improves understanding of COVID

20 January 2023

Since the start of the pandemic, the CAMS-Oxford Institute (COI) has carried out 11 projects to better understand COVID-19, resulting in 21 published research articles.

Study opens a pathway to better diagnosis and treatment of autoimmune diseases

9 December 2022

A study published in Nature by researchers from Washington University School of Medicine in St. Louis, Stanford University School of Medicine and Oxford University have developed a way to find the crucial protein fragment that drives autoimmunity, as well as the immune cells that respond to it.

Constant genetic surveillance needed to counter multidrug-resistant malaria strains

5 December 2022

Continual monitoring of genetic changes in parasite populations is a powerful tool for analysing malaria outbreaks and identifying emerging multidrug-resistant malaria strains, say researchers from NDM’s Mahidol-Oxford Tropical Medicine Research Unit (MORU).

Lancet study informs WHO guidelines for the treatment of malaria in pregnancy

2 December 2022

The study from the Worldwide Antimalarial Resistance Network (WWARN) provides compelling evidence that artemether-lumefantrine should now replace quinine as the treatment of choice in the first trimester.

Bacterial infections linked to one in eight global deaths, according to GRAM study

22 November 2022

Data showing 7.7 million deaths from 33 bacterial infections can guide measures to strengthen health systems, particularly in low-income settings

New study provides important insights into TB correlates of protection

8 November 2022

Researchers from the Nuffield Department of Medicine’s Jenner Institute have today reported the findings from a study investigating whether previously identified correlates of protection associated with the risk of tuberculosis (TB) disease could also be associated with the risk of infection from the bacteria that causes TB.

Therapeutic HIV vaccine achieves encouraging results

4 November 2022

A phase I/IIa clinical trial that the Nuffield Department of Medicine's Jenner Institute collaborated on has demonstrated that a T-cell therapeutic HIV vaccine was associated with better control of the virus rebound when antiretroviral therapy (ART) was temporarily withdrawn.

Gene associated with better immune response after COVID-19 vaccination identified

17 October 2022

Researchers from the Nuffield Department of Medicine have today reported new findings from a study exploring how certain genes can help generate a strong immune response following vaccination with two commonly used COVID-19 vaccines – identifying a particular gene associated with a high antibody response.

Monkeypox can spread widely within specialist hospital isolation rooms

13 October 2022

A new study found viral monkeypox DNA on multiple surfaces, personal protective equipment, and in air samples in hospital isolation rooms. For some of the samples, the viral particles were capable of replicating and therefore could potentially infect other people.

New computational technique reveals changes to lung function post COVID-19 infection

4 October 2022

To investigate whether the symptoms of ‘long-COVID’ are associated with any long-term damage that reduces the function of the lungs and respiratory system, a study led by University of Oxford researchers used a novel computational approach to assess how COVID-19 may affect long-term lung function.

Study raises hope of pre-school type 1 diabetes screening programme

6 September 2022

Researchers in Oxford have launched the first UK study in the general population to test for early markers of type 1 diabetes before children develop symptoms or need insulin.

New monkeypox treatment trialled at Oxford University

23 August 2022

The team behind the world-leading RECOVERY trial of COVID-19 treatments are leading a new study investigating a potential treatment for people who have been diagnosed with monkeypox. The National Institute for Health and Care Research (NIHR) has commissioned and funded the study and the first patients have now been recruited.

First clinical trial data for new rabies vaccine candidate demonstrates promising immune response and safety

27 July 2022

Researchers from the University of Oxford have today reported new findings from a Phase 1 clinical trial studying the immune response and safety of their newly-developed single shot rabies vaccine, ChAdOx2 RabG.

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