Researchers at NDM\u2019s Oxford University Clinical Research Unit (OUCRU) have identified gene activity signatures in the blood of patients with a life-threatening form of tuberculosis.
Scientists in the Nuffield Department of Medicine and the Icahn School of Medicine at Mount Sinai have developed an innovative antibody platform aimed at tackling one of the greatest challenges in treating rapidly evolving viruses like SARS-CoV-2: their ability to mutate and evade existing vaccines and therapies.
In a world first, researchers at the Kennedy Institute of Rheumatology and the Nuffield Department of Medicine have mapped the cellular dynamics following treatment with the most commonly used advanced therapy in autoimmune diseases. They have discovered why some patients benefit from this therapy while others do not, potentially paving the way for new therapies.
A new study from researchers in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC), hosted at NDM\u2019s Pandemic Sciences Institute, reveals the key Long COVID characteristics affecting populations worldwide, including fatigue, shortness of breath and having trouble thinking clearly.
A new study published in Nature Communications has identified a new potential transmission route for H5 highly pathogenic avian influenza viruses (HPAI). Understanding actual \u201cbird flu\u201d rates in humans will help prevent further spillover and a potential new pandemic.
In a new study, published in NPJ Vaccines, researchers from the Pandemic Sciences Institute and The Pirbright Institute have generated new evidence supporting the development of a universal influenza vaccine.
A promising human vaccine candidate against the potentially deadly Rift Valley fever, a mosquito-borne disease affecting countries across Africa, is set to begin Phase II trials in Kenya. This is the most advanced stage of testing a human Rift Valley fever vaccine has reached in an outbreak-prone area to date. A team of scientists at the Nuffield Department of Medicine and the KEMRI-Wellcome Trust Research Programme will lead the $3.7m trial, funded by the Coalition for Epidemic Preparedness Innovations (CEPI).
The Van den Eynde group at the Ludwig Institute for Cancer Research have identified a new CD8+ T-cell epitope of the MAGE-type P1A tumour antigen presented in a widely-used tumour model, opening new perspectives for mechanistic studies looking at MAGE-type specific anti-tumour immunity.
Researchers at Ludwig Institute for Cancer Research in the Nuffield Department of Medicine have found that cancer mutations are not solely caused by a random chemical reaction, but the human DNA polymerase \u03b5 makes errors which result in cytosine to thymine mutations.
Researchers from the Centre for Tropical Medicine and Global Health at NDM have contributed to a new study which will help inform World Health Organization guidelines for treating children with Plasmodium vivax malaria. They found that giving children higher doses of primaquine substantially reduced recurrences of malaria.
The Song group at Ludwig Oxford in the Nuffield Department of Medicine have published a technique for mapping the pseudouridine landscape across the human transcriptome.
The Boccellato group at NDM\u2019s Ludwig Institute for Cancer Research have studied the regulation of antimicrobial peptide secretion in the mucus and its role in determining the colonisation of a pathogen association with stomach cancer.
High levels of acceptability for a point-of-care testing service to improve antibiotic distribution for in Vietnamese pharmacies have been discovered by the Oxford University Clinical Research Unit (OUCRU), part of the Nuffield Department of Medicine.
Research on sickle cell disease conducted by KEMRI-Wellcome Trust Research Programme (KWTRP) at the Nuffield Department of Medicine shows significant progress in understanding how to improve survival rates and quality of life for those living with the condition.
A recent study identified key factors contributing to the tuberculosis burden in Ho Chi Minh City, conducted by researchers from the Oxford University Clinical Research Unit in Vietnam (OUCRU), part of the Nuffield Department of Medicine, and Pham Ngoc Thach Hospital.
Based on estimates across 204 countries and territories, new forecasts from the Global Research on Antimicrobial Resistance (GRAM) Project suggest that bacterial antimicrobial resistance (AMR) will cause 39 million deaths between 2025 and 2050 \u2013 equating to three deaths every minute.
Four years after being derailed by scientific fraud and politicised science in the first year of the pandemic, COPCOV, the world\u2019s largest COVID-19 chemoprevention study, finally published results today that showed that hydroxychloroquine (HCQ) does have a moderate benefit in preventing COVID-19.
Researchers in the Nuffield Department of Medicine, supported by NIHR Oxford Biomedical Research Centre (BRC), have discovered a link between potentially pathogenic bacteria and airways inflammation in people with severe asthma.
The Van den Eynde groups at the Ludwig Institute for Cancer Research in Brussels and Oxford have demonstrated that deletion of PHD2/3 enzymes in CD8 T cells shows an enhanced tumour response in various cancer models.
Researchers at the University of Oxford and the University of Liverpool have for the first time been able to estimate the current burden of Lassa fever, project the impacts of a Lassa fever vaccination programme, and demonstrate how it may help avoid the next pandemic.
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