Owen Siggs 

Graduate Research Prize Winners 2012 


Born and raised in Australia, I started my PhD in 2007 at The Scripps Research Institute (TSRI) in La Jolla, California, supported by a General Sir John Monash Award. Here I took an opportunity to enrol in a joint PhD/DPhil program between TSRI and Oxford, with further support from the Skaggs family.

My research began at TSRI in the laboratory of Professor Bruce Beutler, who in 2011 shared the Nobel Prize in Physiology or Medicine for his discovery of the role of TLR4 in innate immunity. Using an accelerated version of the same approach used to find TLR4, I searched for other proteins that were essential for an immune response. Several unexpected candidates were discovered along the way, including ATP11C and ZBTB1 (required for lymphocyte development) and iRhom2 (required for inflammation).

Moving to Oxford in 2011, I joined the group of Professor Richard Cornall. Here I've continued to study inherited immune disorders, making the most of the outstanding sequencing and bioinformatics resources at the Wellcome Trust Centre for Human Genetics. Beyond the lab I've also been an active member of Lincoln College, and the University men's water polo team.



* Indicates equal contribution