Graduate Research Prize Winners 2012
Born and raised in Australia, I started my PhD in 2007 at The Scripps Research Institute (TSRI) in La Jolla, California, supported by a General Sir John Monash Award. Here I took an opportunity to enrol in a joint PhD/DPhil program between TSRI and Oxford, with further support from the Skaggs family.
My research began at TSRI in the laboratory of Professor Bruce Beutler, who in 2011 shared the Nobel Prize in Physiology or Medicine for his discovery of the role of TLR4 in innate immunity. Using an accelerated version of the same approach used to find TLR4, I searched for other proteins that were essential for an immune response. Several unexpected candidates were discovered along the way, including ATP11C and ZBTB1 (required for lymphocyte development) and iRhom2 (required for inflammation).
Moving to Oxford in 2011, I joined the group of Professor Richard Cornall. Here I've continued to study inherited immune disorders, making the most of the outstanding sequencing and bioinformatics resources at the Wellcome Trust Centre for Human Genetics. Beyond the lab I've also been an active member of Lincoln College, and the University men's water polo team.
- Siggs, O.M.*, N. Xiao*, Y. Wang, H. Shi, W. Tomisato, X. Li, Y. Xia, and B. Beutler. 2012c. iRhom2 is required for the secretion of mouse TNF alpha. Blood. 119:5769–5771. PMID: 22550345
- Siggs, O.M., X. Li, Y. Xia, and B. Beutler. 2012b. ZBTB1 is a determinant of lymphoid development. J Exp Med. 209:19–27. PMID: 22201126
- Siggs, O.M.*, J.T. Cruite*, X. Du, S. Rutschmann, E. Masliah, B.A. Beutler, and M.B.A. Oldstone. 2012a. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proc Natl Acad Sci USA. PMID: 22869751
- Siggs, O.M., B. Schnabl, B. Webb, and B. Beutler. 2011b. X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C Proc Natl Acad Sci USA. 108:7890–7895. PMID: 21518881
- Siggs, O.M., C.N. Arnold, C. Huber, E. Pirie, Y. Xia, P. Lin, D. Nemazee, and B. Beutler. 2011a. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow Nat Immunol. 12:434–440. PMID: 21423172
- Siggs, O.M., M. Berger, P. Krebs, C.N. Arnold, C. Eidenschenk, C. Huber, E. Pirie, N.G. Smart, K. Khovananth, Y. Xia, G. McInerney, G.B. Karlsson Hedestam, D. Nemazee, and B.A. Beutler. 2010. A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha Proc Natl Acad Sci USA. 107:3046–3051. PMID: 20133626
* Indicates equal contribution