Crosstalk between the tumour suppressor p53 and inflammation pathways

Project Overview

The tumour suppressor p53 is the most mutated gene in human cancers and there is extensive knowledge of its vital role in protection against tumorigenesis. But p53 does not act alone: indeed, there are important known regulators of this transcription factor, including the ASPP proteins, and several signalling pathways interact with the p53 axis. This project will investigate crosstalk between the p53 pathway and inflammation. There is strong evidence linking inflammation – particularly chronic inflammatory conditions, such as Crohn’s Disease and Barrett’s Oesophagus – to cancer. However, the molecular mechanisms underlying these links remain to be fully elucidated. Understanding the details of the relationship between p53 and inflammation will be crucial for developing new approaches for early intervention to prevent cancer progression. This project may also extend to crosstalk of p53 with the immune system, such as in the context of immunotherapy for cancer: an emerging therapeutic strategy that is showing great success in some patients.

Training Opportunities

A wide range of molecular and cellular biology techniques including DNA, RNA and protein analysis methods. In addition, mouse developmental biology techniques, in vivo models and other approaches including, but not limited to, tissue culture, in situ hybridisation, confocal microscopy, time lapse imaging and flow cytometry.

Theme

Cancer Biology and Immunology & Infectious Disease

Admissions

Project reference number: 743

Funding and admissions information

Supervisors

Name Department Institution Country Email
Professor Xin Lu Oxford Ludwig Institute Oxford University, Old Road Campus Research Building GBR xin.lu@ludwig.ox.ac.uk
Professor Mads Gyrd-Hansen Oxford Ludwig Institute Oxford University, Old Road Campus Research Building GBR mads.gyrd-hansen@ludwig.ox.ac.uk

There are no publications listed for this DPhil project.