Genes and environment in type 1 diabetes

Project Overview

This project will use a model of type 1 diabetes to investigate the impact of microbiome alterations on the immune system and on the cumulative incidence of diabetes. This work will use cutting edge techniques including single cell RNA-sequencing to dissect the relationship between the host genome, microbiome and autoimmunity. The project will have a particular focus on understanding the function(s) of the novel type 1 diabetes gene DEXI, building upon the work in this manuscript:

Training Opportunities

The training opportunities incude working with an in vivo model; single cell RNA-seq and bulk RNA-seq analysis; microbiome analysis; standard laboratory techniques including DNA and RNA extraction, PCR, western blotting, ELISA, tissue culture, qPCR; flow cytometry; working with large data sets e.g. metabolomics.


Genetics & Genomics and Endocrinology & Metabolic Medicine


Project reference number: 994

Funding and admissions information


Name Department Institution Country Email
Chris O'Callaghan Centre for Cellular and Molecular Physiology Oxford University, Henry Wellcome Building for Molecular Physiology GBR
Professor Lucy Davison Nuffield Dept Medicine University of Oxford GBR

There are no publications listed for this DPhil project.