Health economic evaluation of direct-acting antivirals for hepatitis C treatment in Vietnam

Project Overview

The World Health Organization (WHO) estimates that there are 71 million people living with chronic hepatitis C infection globally. The recent development of Direct-acting antiretroviral drugs (DAAs) has revolutionized hepatitis C treatment. Although improving, the global scale-up of DAA treatment has been markedly uneven, with a handful of countries accounting for the majority of the increase in uptake. A WHO analysis of country experiences of DAA scale-up has shown that, while access to affordable treatment is key, countries need a strong government response, national plans for preventing, diagnosing and treating hepatitis C, and adequate financing to roll out and sustain hepatitis C services. For this to occur, it is vital to have a detailed understanding of the cost and cost-effectiveness of the different treatment options available in low- and middle-income countries. However, these data are currently limited for these settings. This project will conduct a detailed economic evaluation of direct-acting antivirals for hepatitis C treatment in Vietnam. Understanding the cost and cost-effectiveness of DAA based treatment is essential in order to effectively advocate for patients and enable policymakers in Vietnam and other similar settings to enhance accessibility to treatment.

This health economic evaluation study will be incorporated within the VIETNARMS trial. This is a multi-arm randomized controlled trial of DAA treatment strategies for HCV, providing a comparison of two WHO-approved pan-genotypic DAAs. The following research questions will be addressed:

Research questions:

Location(s) of studies: Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

Candidate Requirements: Must be Vietnamese, hold a Masters/MD (preferred) or BSc (essential), and with English language level of IELTS 7.0 (or equivalent).  The candidate should have a Public health or relevant/comparable degree, knowledge and experience in health economic analysis and proven written English and communication skills.  Strong interpersonal skills with an ability to communicate with medical practitioners is desirable as is previous work on hepatitis C.


“Special notice:  Successful applicants shall be enrolled in a DPhil/PhD course at either the University of Oxford (UK) or Open University (UK).  Our PhD programme with these universities has been running for more than 15 years and the degrees awarded are internationally recognized and of the highest quality. We are currently working with the Vietnam Ministry of Education and Training (MOET) to ensure these degrees are fully recognized within Vietnam. However, there remains a risk that recognition will not be granted to students enrolled in this intake. If this concerns you then you are welcome to contact us to discuss the situation and obtain further guidance –”


              Primary supervisor: Prof Guy Thwaites

              Cosupervisor(s): Dr Hugo C Turner



Training Opportunities

Training Opportunities:

Advanced in-house training in health economics and mathematical modelling Relevant external training courses will also be identified depending on the background of the student).

Applications should be sent to prior to the deadline of 30th September 2019.


Tropical Medicine & Global Health and Clinical Trials & Epidemiology


Project reference number: 1039

Funding and admissions information


Name Department Institution Country Email
Guy Thwaites Tropical Medicine Oxford University, Ho Chi Minh City VNM
Hugo Turner Oxford University,

There are no publications listed for this DPhil project.