Murine modelling of non-typeable haemophilus influenzae in lower airways inflammation

Project Overview

Aim: to discover the immunological mechanism underlying the dramatic recent observation that macrolide antibiotics reduce exacerbations in asthma. Our emerging data suggest this effect is related to NTHi infection.

Asthma affects 350 million people worldwide. Non-typeable haemophilus influenzae (NTHi) is a major cause of mucosal infections such as exacerbations of chronic obstructive pulmonary disease and asthma, otitis media, sinusitis and also invasive disease including pneumonia and meningitis. Little is understood about how this pathogen establishes a chronic infection on mucosal surfaces which can prove very resistant to antibiotic treatment and can drive inflammation which does not respond to treatment with inhaled steroids.

Our collaborators at Harwell MRC have developed unique murine models using mice which are genetically susceptible to haemophilus infections. To date these have only been used to investigate otitis media. In this project the DPhil candidate will develop these models to investigate how NTHi drives steroid-resistant inflammation in allergic airways disease.

Training Opportunities

The DPhil candidate will acquire expertise in cellular immunology, in using murine models of human disease, in multiparameter flow-cytometry, in fluorescent imaging and in microbiological techniques.

Theme

Immunology & Infectious Disease

Admissions

Project reference number: 936

Funding and admissions information

Supervisors

Name Department Institution Country Email
Dr Timothy Hinks MRCP Experimental Medicine Division Oxford University, John Radcliffe Hospital GBR timothy.hinks@ndm.ox.ac.uk
Professor Paul Klenerman Experimental Medicine Division Oxford University, Peter Medawar Building GBR paul.klenerman@medawar.ox.ac.uk

There are no publications listed for this DPhil project.