Single cell analysis of B and T cell reconstitution during and after immunomodulatory therapy in autoimmune diseases and cancer

Project Overview

Figure. BCR networks of representative SLE patient blood samples before and after 3 months of ...

We have shown that B cell depletion therapy and/or immunosuppression therapy in patients with a range of autoimmune diseases is associated with significant changes in B cell repertoires reflecting different mechanisms of B cell modulation. However, the effect of different therapeutic interventions on B and T cell function and the resulting reconstitution is not well understood, particularly in relationship to patient prognosis. This project will apply single-cell genetic technologies to investigate the determinants of B and T cell persistence and reconstitution during and after therapy in autoimmune disease. This will be achieved through the development and application of novel experimental and computational approaches, working in partnership with a global network of clinicians, immunologists and sample cohorts.This information may be used to develop potential biomarkers of resistance to therapy and to determine potential therapeutic interventions that could be combined with the current standard of care that could target persistent clones in autoimmune diseases.

Aim

To investigate the determinants of B and T cell persistence and reconstitution during and after therapy in autoimmune disease and the association with outcome.

Training Opportunities

Training Opportunities

The DPhil will gain experience and training in laboratory molecular biology and single cell methods, bioinformatics and immunology. These include:

Theme

Immunology & Infectious Disease and Cancer Biology

Admissions

Project reference number: 982

Funding and admissions information

Supervisors

Name Department Institution Country Email
Rachael Bashford-Rogers Wellcome Trust Centre for Human Genetics Oxford University, Henry Wellcome Building of Genomic Medicine GBR rb520@cam.ac.uk
Professor John A Todd FRS FMedSci Wellcome Trust Centre for Human Genetics Oxford University, Henry Wellcome Building of Genomic Medicine GBR john.todd@well.ox.ac.uk

There are no publications listed for this DPhil project.