The analysis of biomolecules in biological and clinical samples often provides clues about biomedical processes in health and disease. Mass spectrometry has emerged as a key analytical technology in this area.
One of the focuses of the laboratory is to understand how the Ubiquitin-Proteasome System is linked to disease processes. The central element of this pathway is the small protein ubiquitin that can be attached to proteins as a "mark" so that they can be recognized, transported to where in the cell they are needed or eliminated. The molecules that destroy these marked ("ubiquitinated") proteins are called proteases that can chop them into small pieces (peptides and amino acids).
We are particularly interested in using cell biological, biochemical and proteomics & mass spectrometry based approaches to study the biology of ubiquitin processing enzymes and other proteases. We are also interested in understanding their role in immunity and cancer related disease pathologies.
Podcast created by NDM for Proteomics & Kessler Group
In our group, we are focussed on using proteomics, mass spectrometry and biochemical approaches to understand the molecular basis of disease processes. The laboratory hosts a platform containing a variety of chromatography equipment and mass spectrometers. We collaborate with many researchers across the University of Oxford campus and elsewhere, applying this technology in the context of biomedical research.