Deliberately Losing Control of C−H Activation Processes in the Design of Small‐Molecule‐Fragment Arrays Targeting Peroxisomal Metabolism
Khan Tareque R., Hassell‐Hart S., Krojer T., Bradley A., Velupillai S., Talon R., Fairhead M., Day IJ., Bala K., Felix R., Kemmitt PD., Brennan P., von Delft F., Díaz Sáez L., Huber K., Spencer J.
AbstractCombined photochemical arylation, “nuisance effect” (SNAr) reaction sequences have been employed in the design of small arrays for immediate deployment in medium‐throughput X‐ray protein–ligand structure determination. Reactions were deliberately allowed to run “out of control” in terms of selectivity; for example the ortho‐arylation of 2‐phenylpyridine gave five products resulting from mono‐ and bisarylations combined with SNAr processes. As a result, a number of crystallographic hits against NUDT7, a key peroxisomal CoA ester hydrolase, have been identified.