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A 20 d drug regimen of aminosidine (= paromomycin) at 12 mg/kg/d in combination with sodium stibogluconate at 20 mg/kg/d proved efficacious and well-tolerated in patients with visceral leishmaniasis in the State of Bihar, India. Eighteen of 22 evaluable patients achieved an ultimate cure. The remaining 4 patients, although not cleared of parasites, had their parasite grade reduced and also improved clinically. This confirms prior findings in Kenyan patients with kala-azar, and indicates that this regimen is a valid alternative to antimonial compounds alone in the State of Bihar, where cases of kala-azar not responding to antimonial drugs and intolerant of pentamidine are increasingly recorded.

Original publication




Journal article


Transactions of the Royal Society of Tropical Medicine and Hygiene

Publication Date





615 - 616


Patna Medical College, Tripolia Social Service Hospital, India.


Humans, Leishmaniasis, Visceral, Antimony Sodium Gluconate, Paromomycin, Drug Therapy, Combination, Pilot Projects, Adolescent, Adult, Aged, Middle Aged, Child, Child, Preschool, Infant, Female, Male