We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance.
Journal article
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
10/2021
73
e2338 - e2341
Guy's and St Thomas' NHS Trust, United Kingdom.