SARS-CoV-2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide. HLA-based epitope prediction and its association with disease outcomes provide an important base for treatment design. A bioinformatic prediction of T cell epitopes and their restricted HLA class I and II alleles was performed to obtain immunogenic epitopes and HLA alleles from the spike protein of the SARS-CoV-2 virus. Also, a correlation with the predicted fatality rate of hospitalized patients in 28 states of Mexico was done. Here, we describe a set of ten highly immunogenic epitopes, together with different HLA alleles that can efficiently present these epitopes to T cells. Most of these epitopes are located within the S1 subunit of the spike protein, suggesting that this area is highly immunogenic. A statistical negative correlation was found between the frequency of HLA-DRB1*01 and the fatality rate in hospitalized patients in Mexico. This article is protected by copyright. All rights reserved.
Journal of medical virology
Carrera de Médico Cirujano, Facultad de Estudios Superiores Iztacala, UNAM.