Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The coxsackie B virus and adenovirus receptor (CAR) and the major histocompatibility complex (MHC) class I alpha2 domain have been identified as high-affinity cell receptors for adenovirus type 5 (Ad5) fiber. In this study we show that CAR but not MHC class I allele HLA-A*0201 binds to Ad5 with high affinity when expressed on hamster cells. When both receptors are coexpressed on the cell surface of hamster cells, Ad5 fiber bind to a single high-affinity receptor, which is CAR.

Original publication

DOI

10.1128/jvi.73.5.4513-4517.1999

Type

Journal article

Journal

Journal of virology

Publication Date

05/1999

Volume

73

Pages

4513 - 4517

Addresses

Department of Respiratory Medicine & Allergy, The Guy's, King's College and St. Thomas' Hospitals School of Medicine, Thomas Guy House, Guy's Hospital, London SE1 9RT, United Kingdom.

Keywords

CHO Cells, Animals, Humans, Adenoviruses, Human, Capsid, Receptors, Virus, Capsid Proteins, HLA-A2 Antigen, Gene Expression, Alleles, Cricetinae, Coxsackie and Adenovirus Receptor-Like Membrane Protein