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In this issue of Cancer Cell, Awad et al. report a phase 1b clinical trial combining a personalized vaccine NEO-PV-01 with chemotherapy and anti-PD-1 pembrolizumab in first-line metastatic non-squamous NSCLC. They demonstrate that this treatment regimen was well tolerated and induced neoantigen-specific CD4+ T cell responses with effector phenotype.

Original publication

DOI

10.1016/j.ccell.2022.08.002

Type

Journal article

Journal

Cancer Cell

Publication Date

16/08/2022