Non specific resistance against malaria pre-erythrocytic stages: involvement of acute phase proteins.
Pied S., Tabone MD., Chatellier G., Marussig M., Jardel C., Nosten F., Mazier D.
Levels of different acute phase proteins were compared in sera from parasitaemic and non-parasitaemic women living in a Plasmodium falciparum endemic area of Thailand. The ability of their sera to interfere with hepatic stage development of the parasite was examined. Correlations were found between levels of alpha-1 antitrypsin, alpha-2 macroglobulin, hemopexin and the potential of sera to block hepatocyte invasion by the sporozoite.