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Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a prototype response to a nonpersistent pathogen, we have used such techniques to analyze influenza virus-specific memory CD4 T cells directly from blood. These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct "central memory" CD62L(+) phenotype.

Original publication

DOI

10.1128/JVI.78.13.7284-7287.2004

Type

Journal article

Journal

J Virol

Publication Date

07/2004

Volume

78

Pages

7284 - 7287

Keywords

CD4-Positive T-Lymphocytes, Genes, MHC Class II, HLA-DR Antigens, Humans, Immunologic Memory, L-Selectin, Orthomyxoviridae, Phenotype