Genome-wide profiling of molecular recognition of histone PTMs
Filippakopoulos P., Knapp S.
© Springer International Publishing Switzerland 2015. Genome-wide analysis of reader domain interactions with specific chromatin modifications and family-wide structural characterization of reader domain proteins has significantly contributed to our understanding of chromatin biology. Here, we summarize recent advances for the identification of specific sequences recognized by reader domains, the molecular mechanisms determining specificity of these interactions, as well as genome-wide technologies for the identification of chromatin binding sites mediated by reader modules.