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Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and antimicrobial susceptibility of diarrheagenic Escherichia coli in 346 children under 5 years of age in Ifakara, Tanzania, were studied. Thirty-eight percent of the cases of diarrhea were due to multiresistant enterotoxigenic E. coli, enteroaggregative E. coli, or enteropathogenic E. coli. Strains of all three E. coli categories showed high-level resistance to ampicillin, tetracycline, co-trimoxazole, and chloramphenicol but were highly susceptible to quinolones. Guidelines for appropriate use of antibiotics in developing countries need updating.


Journal article


Antimicrob Agents Chemother

Publication Date





3022 - 3024


Child, Preschool, DNA, Bacterial, Diarrhea, Drug Resistance, Microbial, Drug Resistance, Multiple, Escherichia coli, Escherichia coli Infections, Feces, Genes, Bacterial, Humans, Infant, Microbial Sensitivity Tests, Polymerase Chain Reaction, Tanzania