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The efficacies of the azalide azithromycin and the fluoroquinolones trovafloxacin and grepafloxacin for pre- and post-exposure prophylaxis of infection with high or low challenge doses of Burkholderia pseudomallei strain 576 were assessed in an experimental mouse model. Trovafloxacin and grepafloxacin afforded significant levels of protection, whereas azithromycin was ineffective and potentially detrimental. Overall, the data suggest that some fluoroquinolones may have potential utility in prophylaxis of melioidosis and suggest that azithromycin would not be effective in prophylaxis of B. pseudomallei infection.

Original publication

DOI

10.1016/j.ijantimicag.2010.03.019

Type

Journal article

Journal

International journal of antimicrobial agents

Publication Date

07/2010

Volume

36

Pages

87 - 89

Addresses

Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.

Keywords

Animals, Mice, Inbred BALB C, Humans, Mice, Burkholderia pseudomallei, Melioidosis, Disease Models, Animal, Azithromycin, Piperazines, Naphthyridines, Fluoroquinolones, Anti-Bacterial Agents, Antibiotic Prophylaxis, Survival Analysis, Female