Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

Willis NJ., Mahy W., Sipthorp J., Zhao Y., Woodward HL., Atkinson BN., Bayle ED., Svensson F., Frew S., Jeganathan F., Monaghan A., Benvegnù S., Jolly S., Vecchia L., Ruza RR., Kjær S., Howell S., Snijders AP., Bictash M., Salinas PC., Vincent J-P., Jones EY., Whiting P., Fish PV.

DOI

10.1021/acs.jmedchem.2c00162

Type

Journal article

Publisher

American Chemical Society (ACS)

Publication Date

2022-05-26T00:00:00+00:00

Volume

65

Pages

7212 - 7230

Total pages

18

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