Alexander LT., Durairaj J., Kryshtafovych A., Abriata LA., Bayo Y., Bhabha G., Breyton C., Caulton SG., Chen J., Degroux S., Ekiert DC., Erlandsen BS., Freddolino L., Gilzer D., Greening C., Grimes JM., Grinter R., Gurusaran M., Hartmann MD., Hitchman CJ., Keown JR., Kropp A., Kursula P., Lovering AL., Lemaitre B., Lia A., Liu S., Logotheti M., Lu S., Markússon S., Miller MD., Minasov G., Niemann HH., Opazo F., Phillips GN., Davies OR., Rommelaere S., Rosas-Lemus M., Roversi P., Satchell K., Smith N., Wilson MA., Wu K-L., Xia X., Xiao H., Zhang W., Zhou ZH., Fidelis K., Topf M., Moult J., Schwede T.

We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.

Protein target highlights in CASP15: Analysis of models by structure providers.

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