A recent study published by Prof Najib Rahman, Clinical Director, Oxford Respiratory Trials Unit explains how 15% of people with malignant effusion develop septations (pockets) within the fluid, which are difficult to treat. TIME3 was a randomised trial assessing the use of intrapleural fibrinolytic, showing no improvement in breathlessness but improved x-ray appearance and possible mortality benefit. This study provides high quality evidence for the rational use of this medication for patients.
Ethics guidelines have evolved to protect vulnerable groups such as pregnant women from research. This has resulted in a lack of research in these populations making them even more vulnerable because of the lack of evidence-based medical care. In this paper, Professor Phaik Yeong Cheah and her collaborators discuss how regulatory frameworks can sometimes lead to a generalized exclusion of pregnant women from research.
Technological potentials have raised high hopes on healthcare access in LMICs like India. However, five years of research by Dr Marco Haenssgen paint a less optimistic picture and show adverse consequences of mobile phone diffusion, which creates more competition and new divisions and leaves the poorest strata of population worse off than before.
Zika virus RNA is frequently detected in the semen after Zika virus infection. To learn more about persistence of viruses in genital fluids, Dr Alex Salam and Professor Peter Horby searched PubMed and found evidence that 27 viruses can be found in human semen. This may have implications for the risk of sexual transmission, embryonic infection, congenital disease, miscarriage, and infection transmission models.
Amanda Rojek and Peter Horby published a review aimed at clinicians who may treat patients with Ebola Virus Disease. This review outlines advances in understanding the clinical presentation, outcomes and long term sequelae of the disease, and outlines the status of experimental vaccines and treatments.
In a recently published paper in The Lancet, Professor Peter Horby outlines potential epidemics in Africa. It is difficult to predict when and where new epidemics might occur so we can be better prepared and have a proactive response.
Severe malnutrition remains common in low-income countries, principally among young children. It usually arises from poor sanitation and infections, besides food insecurity. This comprehensive review by Professor James Berkley describes how research is needed, using modern clinic and laboratory tools, to better understand changes in metabolism, infections and the immune system to improve treatment.