Research Highlights

The power of data mining in diagnosis of childhood pneumonia

The power of data mining in diagnosis of childhood pneumonia

Posted 29/07/2016

Led by Professor Maarten De Vos and Dr Climent Casals-Pascual, scientists from the WTCHG and the Institute of Biomedical Engineering have used machine learning to diagnose childhood pneumonia. Their proposed solution involves smart algorithms that fully automate the interpretation of medical data which can be captured through affordable hardware.

How to tackle toxic protein aggregates in Parkinson’s disease

How to tackle toxic protein aggregates in Parkinson’s disease

Posted 26/07/2016

In Parkinson’s disease, misfolded proteins such as α-synuclein accumulate in neuronal inclusions termed Lewy bodies. George Tofaris’s team from the University of Oxford Clinical Neuroscience Department and Benedikt Kessler from the TDI investigated the role of α-synuclein handling and the death of neurons that represents a hallmark of Parkinson’s disease.

Rare mutations in bowel cancer may identify patients with a better prognosis

Rare mutations in bowel cancer may identify patients with a better prognosis

Posted 21/07/2016

An international collaboration between the University of Oxford and other European institutions has uncovered a correlation between a rare mutation in bowel cancers and a better prognosis, raising the possibility that patients with such tumours may not require chemotherapy after surgery. Dr David Church was joint senior author of the study.

HIV: Nowhere to hide

HIV: Nowhere to hide

Posted 15/07/2016

While HIV is no longer the death sentence it once was, we are yet to defeat it entirely. However, a new study from Oxford University offers hope that HIV will eventually have nowhere to hide. Tom Calver spoke to Professor Lucy Dorrell about her work on clearing HIV from the body.

You can also listen to Professor Dorrell talk about the findings to BBC Radio 4 (1hr 20 minutes in).

Genetics of type 2 diabetes revealed in unprecedented detail

Genetics of type 2 diabetes revealed in unprecedented detail

Posted 15/07/2016

The largest study of its kind into type 2 diabetes has produced the most detailed picture to date of the genetics underlying the condition. Professor Mark McCarthy is quoted on his involvement in the project.

You can listen to Professor McCarthy talk about this project in a podcast.

Toremifene interacts with Ebola virus

Toremifene interacts with Ebola virus

Posted 15/07/2016

Professor Dave Stuart's group have studied the structure of the Ebola virus and the effect of two drugs, toremifene and ibruprofen on the virus. The study was the first to solve the unligated structure of the Ebola virus glycoprotein and the results were published in Nature.

Assessing the need for a schistosomiasis treatment database

Assessing the need for a schistosomiasis treatment database

Posted 15/07/2016

A database of individual participant-level information could benefit schistosomiasis clinical research and treatment policies, according to a study published PLOS Neglected Tropical Diseases.

The study was conducted by a group of researchers from the Centre for Tropical Medicine and Global Health at the University of Oxford, the Luxembourg Institute of Health and TDR (Special Programme for Research and Training in Tropical Diseases).