In this study, an extensive group of adjuvants has been assessed to investigate immunity enhancement against liver-stage malaria through stimulation of T cell responses. Two were found to improve vaccine efficacy against a sporozoite challenge and the mechanism is presented.
Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
7 September 2017
Adjuvants are key components used to enhance vaccine efficacy. Their use has been well characterised to stimulate antibody responses but very little has been investigated regarding their effect on cytotoxic T cell responses.