In studying the control of immune genes, Chris O’Callaghan and colleagues have discovered a new form of regulation in human genes - interacting control elements within an individual gene can flip the switch on the gene in the opposite direction to that expected.
Intragenic transcriptional interference regulates the human immune ligand MICA.
Research
22 August 2018
Disease processes can switch genes on or off in a cell and this can alter the progress of the disease.