“itaconate” – a molecule derived from glucose – “acts as a powerful off switch for macrophages”, thereby reducing inflammation. The discovery published in Nature offers more effective treatment of inflammatory diseases such as arthritis, inflammatory bowel disease and heart disease.
Scientists discover promising ‘off-switch’ for inflammatory diseases
3 April 2018
Researchers in Ireland, the UK, including Roman Fischer and Benedikt Kessler from the Target Discovery Institute and US have discovered a new metabolic process in the body that can switch off inflammation.