Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often considered the default endothelial state, genetic manipulations can modulate both acquisition and loss of venous fate, suggesting that venous identity is the result of active transcriptional regulation.
Venous identity requires BMP signalling through ALK3
Research
29 January 2019
Ludwig Institute's study of venous development by Professor Sarah De Val, identifying a new potential target for anti-angiogenic cancer therapy is now published in Nature Communications.