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Venous identity requires BMP signalling through ALK3

Research

Ludwig Institute's study of venous development by Professor Sarah De Val, identifying a new potential target for anti-angiogenic cancer therapy is now published in Nature Communications.

Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often considered the default endothelial state, genetic manipulations can modulate both acquisition and loss of venous fate, suggesting that venous identity is the result of active transcriptional regulation.

Read the full article

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