Seminars

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Mon 12 Nov 2018 from 11:00 to 12:00

Department of Oncology

MRC Weatherall Institute of Molecular Medicine, WIMM seminar room , Headington OX3 9DS

Fidelity of DNA double strand break repair is embedded in 3D structure of the neighboring chromatin

Dr Fena Ochs

Since the discovery of the first DNA damage-induced histone modification by Bill Bonner in 1998, we know that DNA double strand breaks (DSBs) trigger accumulation of proteins that read these modifications and navigate repair pathways to restore DNA integrity with high fidelity and with minimum... Read more

Since the discovery of the first DNA damage-induced histone modification by Bill Bonner in 1998, we know that DNA double strand breaks (DSBs) trigger accumulation of proteins that read these modifications and navigate repair pathways to restore DNA integrity with high fidelity and with minimum collateral damage to healthy genome. Although the recent addition of shieldin on the list of proteins that carry out this function was a major step forward, we are still lacking a unifying concept to explain how this vital mode of genome maintenance operates in three-dimensional (3D) space of mammalian nucleus. The conundrum is that while active sites of DNA repair are confined to tiny nuclear volumes, the accompanying chromatin responses spread out to megabase distances. Despite this has been noticed already two decades ago in the Bonner study, we do not understand how repair reactions benefit from remote chromatin modifications. Likewise, we do not know how these modifications reflect, and impact on, chromatin architecture. Furthermore, the abundance of chromatin-bound genome caretakers can vary by an order of magnitude for reasons that remain unclear. To answer these questions, we applied super-resolution microscopy to interrogate spatio-temporal chromatin features after DNA breakage. We will provide evidence that chromatin architecture at DSB sites is actively stabilized and that topological integrity of DSB-flanking chromatin lays down a physical fundament for repair fidelity. We will support this by showing that 53BP1 and RIF1, two proteins that sequentially accumulate at DSB sites, form an autonomous functional module that actively maintains globular chromatin structure. We will show that depletion of 53BP1 or RIF1 phenocopies malfunction of cohesin, the key organizer or chromatin architecture, by causing distortion of chromatin topology accompanied by DSB hyperresection. Unexpectedly, we will also show that stabilization of higher-order chromatin structure after DNA breakage operates independently of repair. We will integrate these findings to a conceptual framework suggesting that 53BP1 and RIF1 primarily evolved to safeguard information stored in 3D chromatin and only later were harnessed to foster repair fidelity by locally concentrating ultralow-abundant antagonists of DSB resection such as shieldin.

Audience: Members of the University only

Organisers: Amanda O'Neill

Mon 12 Nov 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

* CANCELLED * Perivascular Macrophages in Health and Disease: Their Emerging Roles in Cancer

Professor Claire Lewis

Evidence has emerged recently for a specialised subset of macrophages, those lying on the abluminal surface of blood vessels, performing an array of essential functions in steady state tissues. These include the phagocytosis of pathogens, tight control of both vascular permeability and tissue... Read more

Evidence has emerged recently for a specialised subset of macrophages, those lying on the abluminal surface of blood vessels, performing an array of essential functions in steady state tissues. These include the phagocytosis of pathogens, tight control of both vascular permeability and tissue integrity, and dampening on inappropriate inflammation. Alternatively, the aberrant activity of these perivascular sentinels contributes to the onset and/or progression of various diseases including cancer, Alzheimer’s disease, multiple sclerosis and type I diabetes. In my talk, I will outline their multifunctional role in cancer, especially their promotion of tumour repair after various forms of anti-cancer treatment (Hughes et al. 2015. Cancer Res. 75: 3479-91. Lewis et al. 2016. Cancer Cell 30:18-25). ---- After completing her DPhil in the Department of Physiology, Anatomy and Genetics in Oxford in 1986, Claire held two postdoctoral positions and a Research Lectureship in the Medical School in Oxford before moving to the Medical School in Sheffield in 1996. She currently holds a Personal Chair in Molecular & Cellular Pathology and heads a research team focussed mainly on the role of macrophage subsets in tumour responses to various anti-cancer treatments. They have also developed ways of using macrophages to target therapeutic genes and viruses to tumours (as reported by the BBC: http://www.bbc.co.uk/news/health-20795977). Her work is currently funded by grants from Cancer Research UK, Prostate Cancer UK, Breast Cancer Now, and the EU, and she sits on the editorial boards of Cancer Research, Blood, Oncoimmunology and J. Clin Invest Insight. She is a new member of the MRC’s Molecular & Cellular Medicines Board and was awarded a DSc by Oxford University in 2006 for her contribution to the field of tumour inflammation.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 12 Nov 2018 from 13:00 to 14:00

WIMM MONDAY SEMINARS

Molecular mechanisms to cope with endoplasmic reticulum stress

Prof David Ron

Audience: Members of the University only

Organisers: Liz Cloke

Mon 12 Nov 2018 from 15:00 to 16:00

BDI seminars

Big Data Institute, Old Road Campus OX3 7LF

Phenome@BDI Seminar: Parental genotypes influencing the environment

Professor Augustine Kong, Alex Young

Audience: Members of the University only

Organisers: Carol Mulligan-John

Tue 13 Nov 2018 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Floor meeting - 2 groups will give an update on the research work in their laboratory

Audience: Members of the University only

Organisers: Liz Rose

Tue 13 Nov 2018 from 14:30 to 15:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Targeting subcellular trafficking behaviour for the design of therapeutic antibodies

Professor E. Sally Ward

Audience: Members of the University only

Organisers: Anne Farmer

Wed 14 Nov 2018 from 12:00 to 13:00

Peter Medawar Building Seminars

Medawar Building, Level 30 Seminar Room, off South Parks Road OX1 3SY

Parallel Evolution and the Emergence of Highly Pathogenic Avian Influenza A Viruses

Dr Marina Escalera Zamudio

Surveillance of avian influenza is crucial for early detection of outbreaks in bird populations. Although virulent phenotypes are complex traits, several molecular determinants of virulence have been well characterised, such as a polybasic proteolytic cleavage site within the Hemagglutinin (HA)... Read more

Surveillance of avian influenza is crucial for early detection of outbreaks in bird populations. Although virulent phenotypes are complex traits, several molecular determinants of virulence have been well characterised, such as a polybasic proteolytic cleavage site within the Hemagglutinin (HA) protein that allows a systemic spread of the infection. We hypothesise that the parallel evolution of highly pathogenic viral lineages from low-pathogenic ancestors may have been facilitated by permissive or compensatory secondary mutations occurring anywhere in the viral genome. We developed a computational method to detect mutations associated to an evolving trait within a given phylogeny (in this case, virulence) and applied it to a phylogenetically informed sample dataset of H7NX viruses (n>300). A panel of over 30 sites strongly associated with the HP phenotype were detected. This panel may function as an early detection system for transitions between LP to HP avian viruses.

Audience: Members of the scientific community

Organisers: Professor Sunetra Gupta

please arrive 5 minutes early to gain access to the building

Thu 15 Nov 2018 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

Sympathetic Neuroimmunity in obesity

Dr Ana Domingos

Audience: Members of the University only

Organisers: Christina Woodward

Thu 15 Nov 2018 from 12:00 to 13:00

CNCB Seminar Series

Oxford Martin School, Oxford Martin School, 34 Broad Street, 34 Broad Street OX1 3BD

The Neuromodulatory Connectome: Wire and Wireless Networks

William Schafer

The synaptic connectome of the nematode C. elegans has been mapped completely, and efforts are ongoing to map the connectomes of other animals. However, chemical synapses represent only one of several types of signaling interaction in the nervous system. In particular, neuromodulation by... Read more

The synaptic connectome of the nematode C. elegans has been mapped completely, and efforts are ongoing to map the connectomes of other animals. However, chemical synapses represent only one of several types of signaling interaction in the nervous system. In particular, neuromodulation by monoamines, neuropeptides, or classical neurotransmitters is widespread and often occurs extrasynaptically between neurons not connected by wired synapses. In C. elegans, it is feasible to map these neuromodulatory networks comprehensively and at a single-cell level and examine how wired and wireless signaling interact. In this talk, I will describe what we have learned about the functional organisation of neuromodulatory circuitry involved in the control of behavioural states such as arousal, as well as our ongoing efforts to map extrasynaptic connectome networks comprehensively in the worm. In addition, I will discuss our identification of new ionotropic receptors for monoamines and other neuromodulators, which may represent novel targets for anti-parasitic drugs.

Audience: Members of the University only

Organisers: Fiona Woods

Thu 15 Nov 2018 from 13:00 to 14:00

Medical Grand Rounds

Radiology / Psychological Medicine

Dr Luke Solomons, Dr Ursula Schulz, Prof Fergus Gleeson

Radiology: "The National Consortium of Intelligent Medical Imaging is open for business", Prof Fergus Gleeson -- Psychological Medicine: "STROKE (I63.3) OR NOT (F44.4)? What is WDZZ22?", Dr Luke Solomons and Dr Ursula Schulz -- Chair: Prof Hugh Watkins

Radiology: "The National Consortium of Intelligent Medical Imaging is open for business", Prof Fergus Gleeson -- Psychological Medicine: "STROKE (I63.3) OR NOT (F44.4)? What is WDZZ22?", Dr Luke Solomons and Dr Ursula Schulz -- Chair: Prof Hugh Watkins

Audience: Members of the University and NHS clinical staff.

Thu 15 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

UBVO Seminar: Psychosocial inequality, insecurity and overweight/obesity in a Danish youth cohort

Per Høgh Poulsen

Audience: Members of the University only

Organisers: Graham Bagley

Thu 15 Nov 2018 from 14:00 to 15:00

Experimental Medicine TGU Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Microbial-host interactions involved in obesity and the response to bariatric surgery

Dr Carolina Arancibia, Dr Alessandra Geremia, Dr Valentina Greto

Obesity has reached alarming levels in the UK. According to a government report, one in four adults are obese in the UK. Medical and dietary interventions are often ineffective at inducing weight loss and the best outcomes are obtained after weight loss surgery (also known as bariatric surgery).... Read more

Obesity has reached alarming levels in the UK. According to a government report, one in four adults are obese in the UK. Medical and dietary interventions are often ineffective at inducing weight loss and the best outcomes are obtained after weight loss surgery (also known as bariatric surgery). These surgical procedures were initially thought to work mechanistically through stomach restriction and lower calorie absorption through the shortened intestine. However, recent evidence has challenged this concept and it has been suggested that changes in the gut microbial flora could affect metabolism contributing to weight loss and increased insulin response. Gut flora is beneficial to the host in many ways, contributing to for example, nutrient absorption and a healthy immune system. Abnormalities in the composition of the gut microbes are thought to contribute to the pathology of certain diseases, including obesity and diabetes. The aim of this project is to find out how altered host and microbial functions affect weight loss and metabolism after bariatric surgery. Understanding more about the microbial flora and how this impacts patient’s health will hopefully make way for new approaches in the treatment of obesity and diabetes.

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Thu 15 Nov 2018 from 15:00 to 16:00

Experimental Medicine TGU Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Evaluation of the stromal compartment activation in therapy-refractory inflammatory bowel disease patients that require surgical intervention

Dr Matthias Friedrich

Inflammatory bowel disease (IBD), in its manifestations Crohn’s disease and ulcerative colitis, is a chronic inflammatory disease that can affect all parts of the digestive tract. Environmental factors, genetic predisposition and an abnormal function of the immune system are thought to cause... Read more

Inflammatory bowel disease (IBD), in its manifestations Crohn’s disease and ulcerative colitis, is a chronic inflammatory disease that can affect all parts of the digestive tract. Environmental factors, genetic predisposition and an abnormal function of the immune system are thought to cause IBD.
Standard therapies aim at controlling intestinal inflammation and prolonging the time between disease flare-ups. Although significant progress has been made over the last decades, a high proportion of patients still do not respond to these anti- inflammatory therapies, or become resistant during the course of treatment. Failure to therapeutically control chronic inflammation can lead to severe complications in IBD patients, such as fibrosis, which requires surgical intervention. Fibrotic changes in the intestine are driven by an activation of a particular cell type, the fibroblast. The aim of this project is to find out whether IBD patients that go on to require surgery display an activation of fibroblasts, and which changes in the tissue are associated with this activation. For this, differences in the way the surgically removed fibrotic tissue is programmed will be compared to the programming of non-inflamed ‘normal’ tissue. We believe that certain alterations in this programming, which is controlled by a network of signals, can lead to changes that are specifically associated with inflammation and the requirement for surgery. Differences in the networks of signals which make up this program of inflamed and non-inflamed tissue will help us identify novel, fibroblast-targeting, therapies which will disrupt the inflammation program and hopefully reduce the requirement for surgery.

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Fri 16 Nov 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Hearing Loss and Public Health - is anybody listening?

Professor Gerry O'Donoghue

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 16 Nov 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Follicular connections: bloody Tfh cells in sight

Elena Brenna

Audience: Members of the University only

Organisers: Anne Farmer

Fri 16 Nov 2018 from 12:00 to 13:00

WHG Seminars

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

An immunogenetics approach to studying immune-cell involvement in ankylosing spondylitis

Aimee Hanson

Audience: Members of the University only

Organisers: Isabel Schmidt

Fri 16 Nov 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Macrophage contribution to Insulin Resistance independently of Inflammation

Dr Myriam Aouadi

Since the discovery of macrophages in adipose tissue, many laboratories have focused their effort on understanding the contribution of these immune cells to metabolic diseases. Despite great progress in characterizing obesity as a state of low-grade inflammation, very little is known about the... Read more

Since the discovery of macrophages in adipose tissue, many laboratories have focused their effort on understanding the contribution of these immune cells to metabolic diseases. Despite great progress in characterizing obesity as a state of low-grade inflammation, very little is known about the multiple phenotypes and functions of macrophages in metabolic tissues. The lack of methods to carefully investigate cell-to-cell variability in macrophage phenotype and to manipulate gene expression in a cell-specific manner has delayed answering these crucial questions. Our lab takes advantage of sophisticated methods, such as next generation sequencing, CytOF and gene silencing in a cell specific manner, to investigate macrophage subpopulations and their function in obesity-associated metabolic complications.

Audience: Members of the University only

Mon 19 Nov 2018 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c, Headington OX3 7DQ

Developing T cell receptor therapies to target cancer

Marco Lepore, David Cole

Immunotherapies that activate patient’s T cells to attack cancer cells have a potential to eradicate tumours. Although therapies using monoclonal antibodies have been proven effective, they are limited to targeting cell surface proteins. This limitation is overcome by T cell receptor (TCR) based... Read more

Immunotherapies that activate patient’s T cells to attack cancer cells have a potential to eradicate tumours. Although therapies using monoclonal antibodies have been proven effective, they are limited to targeting cell surface proteins. This limitation is overcome by T cell receptor (TCR) based approaches, as TCRs recognize a broad range of peptides presented in the context of human leukocyte antigens (HLAs). At Immunocore, we have developed Immune mobilizing monoclonal TCRs Against Cancer (ImmTAC™), a new class of soluble bi-specific biologics comprising affinity-enhanced TCR fused to an anti-CD3 effector domain. ImmTAC molecules recognize a specific target peptide presented by HLA on tumour cells and redirect the patient’s T cells to carry out potent tumour cell killing. Development of ImmTAC molecules is a multi-step process where safety and specificity are the key considerations. Key is affinity maturation of the TCR through mutagenesis of CDR loops. The highest-affinity mutants are further screened for specificity and cross-reactivity using a range of cellular assays. This process has been successfully applied to produce ImmTAC molecules for a number of targets, demonstrating the robustness of the platform. As an example, IMCgp100, an ImmTAC recognizing melanoma associated protein gp100, is currently undergoing clinical trials in patients suffering from advanced malignant melanoma.

Audience: Members of the University only

Organisers: Amanda O'Neill

Mon 19 Nov 2018 from 12:00 to 13:00

OPDC Seminar Series (DPAG)

Sherrington Library, Sherrington Library, 2nd floor, off Parks Road OX1 3PT

Using transcriptomics to understand neurodegenerative disorders

Dr Mina Ryten

As an MBPhD graduate (Cambridge University & University College London) and Academic Clinical Fellow in Neurology (London Deanery), I have been lucky enough to receive training in basic research as well as clinical medicine. I have thoroughly enjoyed both and am committed to pursuing a joint... Read more

As an MBPhD graduate (Cambridge University & University College London) and Academic Clinical Fellow in Neurology (London Deanery), I have been lucky enough to receive training in basic research as well as clinical medicine. I have thoroughly enjoyed both and am committed to pursuing a joint clinical and research career in neuroscience. However, I am fully aware that the gap between clinical realities and basic research can be hard to bridge. During my PhD I investigated the role of a specific signalling system, purinergic signalling, in skeletal muscle development and regeneration under the supervision of Professor Geoffrey Burnstock (University College London). Using techniques such as cell culture, RT-PCR and immunohistochemistry, I was able to dissect out the role of an individual signalling pathway. I demonstrated that activation of the P2X5 receptor for ATP potentiated muscle stem cell differentiation and that this process was dependent on activation of the p38 MAP kinase pathway. Since my PhD the advent of high through-put microarray and sequencing-based technologies have made it possible to take a systems approach and so have the potential to provide exciting insights into complex neurological diseases. With this is in mind I have sought to develop new skills in biomedical informatics and currently hold an MRC Post-doctoral Training Fellowship in Biomedical Informatics. This fellowship has given me the opportunity to pursue my interest in the pathophysiological basis of risk genetic loci for neurodegenerative diseases and that is the focus of my current research.

Audience: Members of the University only

Organisers: Melanie Witt

PLEASE NOTE NEW TIME!

Mon 19 Nov 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Theatre, Headington OX3 7LF

Tertiary lymphoid structures: autoimmunity goes local

Dr Francesca Barone

Detection of germinal center-like structures within tertiary lymphoid organs (TLS) in the salivary glands of patients with Sjogren’s syndrome (SS) is associated with increased risk of lymphoma. Moreover, histological analysis of salivary glands is currently used as a prognostic tool in clinical... Read more

Detection of germinal center-like structures within tertiary lymphoid organs (TLS) in the salivary glands of patients with Sjogren’s syndrome (SS) is associated with increased risk of lymphoma. Moreover, histological analysis of salivary glands is currently used as a prognostic tool in clinical practice and the disaggregation of TLOs in post-treatment biopsies is considered a valid measure of positive outcome in ongoing clinical trials. Nonetheless, the biological role of TLS in inflammation remains unclear. How do these structures form and how do they differ from a physiological secondary lymphoid organ? Are those differences at the core of the autoimmune process in SS? ---- During her undergraduate course in Italy, Francesca developed a strong interest in research and, after obtaining her degree, decided to suspend her clinical training to undertake a PhD. She relocated to London to investigate the mechanisms that regulate the acquisition of lymphoid organ features in salivary gland inflammatory infiltrates of Sjogren’s Syndrome patients, with particular focus on the factors that regulate lymphocyte organization and survival within the gland. She obtained her Specialization as a rheumatologist in 2007 followed by her PhD in 2008. At Kings College London, she embarked on a period of post-doctoral studies examining the physiological biology of mucosal B cells, whilst also working as an honorary rheumatology consultant at Guy’s Hospital. In 2010 Francesca moved to Birmingham to study the mechanisms regulating leukocyte/stromal cell interaction in humans and animal models of inflammatory diseases. She obtained a Wellcome Trust Clinician Scientist fellowship in July 2010 to develop her research interest and start her own independent group. Francesca currently works as a consultant rheumatologist in both the University Hospitals Birmingham (UHB) and also the Sandwell and West Birmingham Trusts, with a main clinical interest in inflammatory arthritis and Sjogren’s syndrome. Since 2014 she has been the Head of the eSSential – EULAR Sjogren’s Syndrome Experimental aNd Translational Investigative Alliance (EULAR) study group. In 2016 Francesca obtained a Senior Research Fellowship from ARUK (now Versus Arthritis) to exploit the mechanisms enabling the persistence of tertiary lymphoid structures (TLS) in inflamed tissue and to investigate the pathogenicity of stromal cells in TLS-associated diseases.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 19 Nov 2018 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

The Role of Protein Complexes in Human Genetic Disease

Dr Joe Marsh

Audience: Members of the University only

Organisers: Liz Cloke

Tue 20 Nov 2018 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Balancing cell potency and specification in stem cells and in the early embryo

Dr Veronique Azuara

Audience: Members of the University only

Organisers: Liz Rose

Tue 20 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Wed 21 Nov 2018 from 09:15 to 10:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

“How does leukaemia disrupt hematopoiesis?” Viva Seminar

Audience: Members of the University only

Organisers: Sarah Butler

Viva Seminar

Wed 21 Nov 2018 from 11:00 to 12:00

Jenner Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Neo-antigen based cancer vaccines

Prof Alfredo Nicosia

Audience: Public

Organisers: Lisbeth Soederberg

Wed 21 Nov 2018 from 11:30 to 12:30

WHG Lunchtime Lab Talks

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

Lunter and Stuart Lunchtime Lab Talks

Richard Brown, Daniel Cooke, Dr Luigi De Colibus, Helen Duyvesteyn

Lunter Group Speaker: Richard Brown Title: ‘A Deep Learning Model for Splice Site Prediction’ Speaker: Daniel Cooke Title: ‘A unified haplotype-based method for accurate and comprehensive variant calling’ Stuart Group Speaker: Luigi De Colibus Title: ‘Assembly of complex viruses... Read more

Lunter Group Speaker: Richard Brown Title: ‘A Deep Learning Model for Splice Site Prediction’ Speaker: Daniel Cooke Title: ‘A unified haplotype-based method for accurate and comprehensive variant calling’ Stuart Group Speaker: Luigi De Colibus Title: ‘Assembly of complex viruses exemplified by a halophilic euryarchaeal virus’ Speaker: Helen Duyvesteyn Title: ‘Structural Studies of Picornaviridae’

Audience: Members of the University only

Organisers: Isabel Schmidt

Please note this has changed to an earlier slot of 11:30-12:30 due to a clash with Sir Mike Ferguson's seminar at the JR https://www.nds.ox.ac.uk/events/litchfield-lecture-2018-19

Wed 21 Nov 2018 from 12:00 to 13:00

Peter Medawar Building Seminars

Medawar Building, Level 30 Seminar Room, off South Parks Road OX1 3SY

Adapting protein quality control for intervention in immunity and neurodegenerative diseases

Heidi Olzscha

Protein folding is tightly regulated by molecular chaperones and other protein quality control mechanisms such as the ubiquitin proteasome system and autophagy to ensure the integrity of the proteome. However, these systems can fail to prevent protein misfolding, leading to protein aggregation and... Read more

Protein folding is tightly regulated by molecular chaperones and other protein quality control mechanisms such as the ubiquitin proteasome system and autophagy to ensure the integrity of the proteome. However, these systems can fail to prevent protein misfolding, leading to protein aggregation and amyloidosis. They are underlying reasons for many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease or Huntington’s disease. Interfering with protein quality control systems and modulating posttranslational modifications of proteins can reduce aggregation, ameliorate amyloidosis and can have profound effects on the immune system.

Audience: Members of the scientific community

Organisers: Professor Sunetra Gupta

please arrive 5 minutes before the seminar to gain entry to the building

Wed 21 Nov 2018 from 13:00 to 14:00

John Radcliffe Hospital, Lecture Theatre 2, Academic Centre

Litchfield Lecture 2018: Basic to Clinical: A translational journey in parasitology and beyond

Professor Mike Ferguson

Audience: All Academic, clinical and support staff, all Graduate and Medical students

Organisers: Kathryn Smith

Wed 21 Nov 2018 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

A Ready Made killer: Preconfiguration of the chromatin landscape and fate determination for virus-specific CD8+ killer T cells

Professor Stephen Turner

A consequence of naive CD8+ T cell activation is specific changes in phenotype, proliferation and acquisition of lineage-specific function. The precise gene regulatory mechanisms that control these changes are largely unknown. Using a combination of genome wide sequencing approaches we have... Read more

A consequence of naive CD8+ T cell activation is specific changes in phenotype, proliferation and acquisition of lineage-specific function. The precise gene regulatory mechanisms that control these changes are largely unknown. Using a combination of genome wide sequencing approaches we have examined the wholesale changes in both 3D structure and biochemical modifications associated with virus-specific CD8+ T cell differentiation in response to infection. Our data suggests that lineage-specific fate determination is largely preconfigured, or poised, within mature naive virus-specific CD8+ T cells. More importantly our data suggest that effector differentiation is in fact actively restrained within the naive state by specific molecular mechanisms, with T cell activation resulting in release of this molecular handbrake that triggers transcriptional activation of a highly regulated differentiation program that underpins induction of an optimal effector killer T cell response. Understanding these mechanisms is key for understanding not only how optimal CD8+ T cell effector function is established but it has implications for our understanding of how immunological memory is established, and how we may modulate this process for therapeutic gain.

Audience: Members of the University only

Organisers: Anne Farmer

Thu 22 Nov 2018 from 13:00 to 14:00

Medical Grand Rounds

Tropical Medicine Day

Tropical Medicine: -- Tropical Medicine: -- Chair: TBA

Tropical Medicine: -- Tropical Medicine: -- Chair: TBA

Audience: Members of the University and NHS clinical staff.

Thu 22 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

UBVO Seminar: Assessing the reformulation efforts of soft drinks companies in the UK

Lauren Bandy

Audience: Members of the University only

Organisers: Graham Bagley

Thu 22 Nov 2018 from 17:00 to 19:00

Centre for Personalised Medicine Seminars

Mathematical Institute, Woodstock Road OX2 6GG

CPM Annual Lecture 2018 - Professor Charles Swanton

Professor Charles Swanton

We are delighted to invite you to the Centre for Personalised Medicine’s Annual Lecture on 22 November 2018 in the Mathematical Institute, Oxford. This year’s speaker is Professor Charles Swanton of the Francis Crick Institute, talking on cancer chromosomal evolution in metastases and immune... Read more

We are delighted to invite you to the Centre for Personalised Medicine’s Annual Lecture on 22 November 2018 in the Mathematical Institute, Oxford. This year’s speaker is Professor Charles Swanton of the Francis Crick Institute, talking on cancer chromosomal evolution in metastases and immune escape - insights from Tracerx. There will be a drinks reception at 17:00, followed by the lecture at 18:00. All interested persons are invited to attend. www.well.ox.ac.uk/cpm/2018-annual-lecture

Booking Required

Audience: Public

Organisers: Catherine Lidbetter

Fri 23 Nov 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Avoiding obsolescence as a cancer surgeon - a few survival tips

Professor Declan Murphy

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 23 Nov 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Spontaneous and targeted disruption of thymus development and function: Lessons learnt

Wei Wu, Ioanna Rota, Prof Georg Holländer, Stanley Cheuk

Audience: Members of the University only

Organisers: Anne Farmer

Fri 23 Nov 2018 from 12:00 to 13:00

WHG Seminars

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

NGS of Immune Repertoire for biomarker discovery

Dr Jian Han

Since 2007, we have been working on developing technologies and software tools to study immune repertoires. We have studied more than 40,000 samples and accumulated the most complete set of database on normal and patient repertoires. Based on deep knowledge and vast data, we have developed many... Read more

Since 2007, we have been working on developing technologies and software tools to study immune repertoires. We have studied more than 40,000 samples and accumulated the most complete set of database on normal and patient repertoires. Based on deep knowledge and vast data, we have developed many clinical applications, for example: (1) Sharing Index, describing a person repertoire overlapping with a disease signature, therefore, can be used for disease diagnoses; (2) Delta Index, describing the repertoire turn over rate and can be used to monitor treatment; (3) Essential and Diversity Indexes, evaluating repertoire diversity and provide an estimate of a person’s immune reserve; (4) Response Index, evaluate potential of responding to immune therapies. There are many technical challenges for sequencing immune repertoires. The method of library construction need to be inclusive, quantitative, and noise free. We have developed several multiplex PCR technologies (tem-PCR, arm-PCR, and dam-PCR) that allow us to amplify all 7 chains of T and B cell receptors from one sample, quantitatively. It also allowed us to study single cell to pair multiple chains of receptors and providing phenotype information at the same time. Sequencing immune repertoire is quite different from sequencing genomic DNA: Rather than re-sequencing a pubic genome, we perform de novo sequencing of private repertoires; the size of genome is known, while the size of repertoire universe is unknown; the genome is static, the repertoire is dynamic and changing every day; sequencing genome is to learn about genotype and physiology, pathways, sequencing repertoire is to learn about interactions with the environment, and is more about pathology and biomarkers. Genome sequencing can predict the future risks of having diseases; repertoire sequencing is trying to find out what our immune system is working on today.

Audience: Members of the University only

Organisers: Isabel Schmidt

Fri 23 Nov 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

GL Brown Lecture (PhySoc) - Seeing depth with two eyes: the binocular physiology of 3D space

Progessor Andrew Parker

Neurons that are specifically tuned to binocular depth were discovered in seminal work published 50 years ago by Horace Barlow, Colin Blakemore and Jack Pettigrew in the Journal of Physiology. Their study in the primary visual cortex opened up the era of understanding the physiology of 3-D... Read more

Neurons that are specifically tuned to binocular depth were discovered in seminal work published 50 years ago by Horace Barlow, Colin Blakemore and Jack Pettigrew in the Journal of Physiology. Their study in the primary visual cortex opened up the era of understanding the physiology of 3-D perception. Thanks to more recent work, we now know that large areas of the extrastriate visual cortex are involved. Sites where binocular stereoscopic depth is integrated with other visual information can be identified and physiological signals related to active perceptual decisions about depth can be isolated. At some sites, a causal role of physiological signals for the perception of depth can be demonstrated by showing that weak electrical microstimulation of the cortex can alter behavioural reports of depth perception. However, there seems to be no single brain module that is responsible for computing stereoscopic depth. This lecture will trace these paths of discovery in human and animal studies. Andrew Parker will show how a better understanding of the physiology of depth perception changes our view of how the brain constructs a representation of the space around us. Findings from this neurophysiological research have implications for the growing popularity of 3-D cinema and immersive virtual reality.

Audience: Members of the University only

Fri 23 Nov 2018 from 14:30 to 15:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Molecular intricacies of T-cell receptor autoreactivity towards CD1 molecules presenting self-lipids

Dr Adam Shahine

Audience: Members of the University only

Organisers: Anne Farmer

Fri 23 Nov 2018 from 17:00 to 19:00

AfOx insaka - a gathering for sharing ideas and knowledge about Africa-focused research

St Cross College, Lecture Theatre, West Wing, St Giles OX1 3LZ

AfOx insaka

Suzanne Wanjaria, Paris Stefanoudis

The AfOx insaka is a gathering for sharing ideas and knowledge about Africa-focused research with speakers from diverse and varied academic disciplines. There are two events each term. On Friday of Week 3, and Friday of Week 7. Each event will feature two talks by speakers from different disciplines, followed by questions and discussion. Drinks will be served afterwards.

The AfOx insaka is a gathering for sharing ideas and knowledge about Africa-focused research with speakers from diverse and varied academic disciplines. There are two events each term. On Friday of Week 3, and Friday of Week 7. Each event will feature two talks by speakers from different disciplines, followed by questions and discussion. Drinks will be served afterwards.

Booking Required

Audience: Public

Mon 26 Nov 2018 from 12:30 to 13:30

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Mon 26 Nov 2018 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

JAK/STAT signalling, stem cell subversion

Professaor Tony Green

Audience: Public

Organisers: Linda Roberts

Mon 26 Nov 2018 from 15:00 to 16:00

BDI seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Phenome@BDI Seminar: Cancer phenotyping

Dr David Wedge, Dan Woodcock

Audience: Members of the University only

Organisers: Carol Mulligan-John

Tue 27 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Richard Doll Seminar: Using naturally randomized genetic evidence to inform the design of randomized trials

Professor Brian Ference

Brian is a cardiologist and genetic epidemiologist who was educated and trained at Harvard, Yale, Oxford and Cambridge Universities. He graduated from Yale Medical School, and trained in clinical epidemiology and genetic epidemiology at Yale. He then trained in cardiology and interventional... Read more

Brian is a cardiologist and genetic epidemiologist who was educated and trained at Harvard, Yale, Oxford and Cambridge Universities. He graduated from Yale Medical School, and trained in clinical epidemiology and genetic epidemiology at Yale. He then trained in cardiology and interventional cardiology at Harvard Medical School where he also completed the Program in Clinical Effectiveness at Harvard School of Public Health, and was an NHLBI Cardiovascular (Genetic) Epidemiology Fellow. He is currently Director of Research in Translational Therapeutics, and Head of the Centre for Naturally Randomized Trials in Cambridge having moved from Wayne State University School of Medicine in Detroit where he was Clinical Chief of Cardiology and Director of the Cardiovascular Genomic Research Centre. His research focuses on using Mendelian randomization to design ‘naturally randomized trials’ to generate evidence that can be used to improve the drug discovery and development process; inform the optimal design of trials; fill evidence gaps when a randomized trial is not possible or practical; and define the practice of precision cardiovascular medicine.

Audience: Members of the University only

Tue 27 Nov 2018 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Floor meeting - 2 groups will give an update on the research work in their laboratory

Audience: Members of the University only

Organisers: Liz Rose

Wed 28 Nov 2018 from 12:00 to 13:00

Peter Medawar Building Seminars

Medawar Building, Level 30 Seminar Room, off South Parks Road OX1 3SY

Host MHC and genomic diversity retards experimental evolution of viral virulence

Professor Wayne Potts

Experimental evolution of a mouse-specific retrovirus in various host genotypes reveal increases in fitness and virulence by 50- and 20-fold respectively. The virus adapts to specific host genotypes as indicated by its’ reduced ability to infect other host genotypes, including those that differ... Read more

Experimental evolution of a mouse-specific retrovirus in various host genotypes reveal increases in fitness and virulence by 50- and 20-fold respectively. The virus adapts to specific host genotypes as indicated by its’ reduced ability to infect other host genotypes, including those that differ only at histocompatibility loci. Three round serial passages where the host genotype is alternated once, dramatically reduces viral fitness and virulence. Full genome sequencing of these evolved viral lines reveal surprising results where no mutations have become fixed despite strong selection operating over 240 generations.

Audience: Members of the scientific community

Organisers: Professor Sunetra Gupta

Please arrive 5 minutes before the seminar to gain access to the building

Wed 28 Nov 2018 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Audience: Members of the University only

Organisers: Anne Farmer

Thu 29 Nov 2018 from 12:00 to 13:00

Population Health Seminars

Richard Doll Building, Lecture Theatre , Old Road Campus OX3 7LF

Richard Doll Seminar: Can we transform perinatal care through larger, more efficient, collectively prioritised international trials?

Professor William Tarnow-Mordi

William is an academic neonatologist, who graduated with first class Honours in Cambridge. He has a globally recognised record of translational research via international multicentre RCTs and cohort studies in >30,000 patients and >200 neonatal units worldwide. Having trained in neonatal medicine... Read more

William is an academic neonatologist, who graduated with first class Honours in Cambridge. He has a globally recognised record of translational research via international multicentre RCTs and cohort studies in >30,000 patients and >200 neonatal units worldwide. Having trained in neonatal medicine in the UK, he moved to Sydney in 1999 as inaugural Chair of Neonatology at Westmead Hospital, University of Sydney and Director of Neonatology. He has been a strong advocate of large multicentre neonatal and perinatal studies to answer key clinical questions and has conducted multiple landmark collaborative studies such as the International Neonatal Immunotherapy Trial, the ECSURF Study, the UK Neonatal Staffing Study, INIS, BOOST II Australia, the Australian Placental Transfusion Study (APTS) of delayed cord clamping and the NeOProM Collaboration of oxygen saturation. Each has contributed to evidence that is likely to save millions of lives in coming years. This raises a new challenge: “In the next decade, can parents, patients, professionals, researchers, policymakers, providers, funders and the public collaborate to embed international trials in routine care that are ten times larger and faster, at one tenth the cost?”

Audience: Members of the University only

Thu 29 Nov 2018 from 13:00 to 14:00

Medical Grand Rounds

Jenner Institute / Silver Star

Prof Adrian Hill, Dr Samantha Chessell, Dr Lauren Green, Dr Charlotte Frise

Jenner Institute: "Therapeutic Vaccines", Prof Adrian Hill -- Silver Star: "Baby, you take my breath away: A presentation on breathlessness in pregnancy", Dr Samantha Chessell, Dr Lauren Green and Dr Charlotte Frise -- Chair: Prof Hugh Watkins

Jenner Institute: "Therapeutic Vaccines", Prof Adrian Hill -- Silver Star: "Baby, you take my breath away: A presentation on breathlessness in pregnancy", Dr Samantha Chessell, Dr Lauren Green and Dr Charlotte Frise -- Chair: Prof Hugh Watkins

Audience: Members of the University and NHS clinical staff.

Thu 29 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

UBVO Seminar: Genomics of common obesity

Cecilia Lindgren

Audience: Members of the University only

Organisers: Graham Bagley

Fri 30 Nov 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Surgical Grand Rounds - Transplant

Professor Peter Friend, Dr David Nasralla

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 30 Nov 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Ogg Group

Audience: Members of the University only

Organisers: Anne Farmer

Fri 30 Nov 2018 from 10:30 to 12:00

WHG Seminars

Wellcome Trust Centre for Human Genetics, CCMP2, Headington OX3 7BN

SINGLE CELL SEMINARS - WELLCOME CENTRE FOR HUMAN GENETICS

Hannah Chen

SINGLE CELL SEMINARS – WELLCOME CENTRE FOR HUMAN GENETICS Friday, November 16, 2018 CCMP2 10:30 -12:00 Postponed to November 30th Hannah Chen for info, please email curion@well.ox.ac.uk

SINGLE CELL SEMINARS – WELLCOME CENTRE FOR HUMAN GENETICS Friday, November 16, 2018 CCMP2 10:30 -12:00 Postponed to November 30th Hannah Chen for info, please email curion@well.ox.ac.uk

Audience: Members of the University only

Fri 30 Nov 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Coping with a stressful start in life

Professor Alex Gould

Joint Seminar with the Dunn School Environmental stresses experienced during development (early-life) exert both short and long-term influences upon health and disease. In most cases, however, the underlying biological response mechanisms remain mysterious. The goal of our research is to... Read more

Joint Seminar with the Dunn School Environmental stresses experienced during development (early-life) exert both short and long-term influences upon health and disease. In most cases, however, the underlying biological response mechanisms remain mysterious. The goal of our research is to understand the molecular nuts and bolts of how early-life environmental stresses alter gene expression, metabolism and physiology. Much of our research uses the powerful genetics of the fruit fly Drosophila, together with analytical techniques such as metabolomics and mass spectrometry imaging. Using this combined approach, we identified molecular mechanisms that protect neural stem cells in the developing CNS from the immediate harmful effects of malnutrition and hypoxia. For example, we found that hypoxia induces lipid droplets in the local microenvironment (niche) of the neural stem cells. Droplets function to protect neural stem cells from lipid peroxidation damage, likely by sequestering potentially vulnerable polyunsaturated fatty acids in their core. We have also begun investigating the longer-term impact of early-life stresses upon longevity. Recent work shows that developmental exposure to mild oxidative or nutritional stress can, in some cases, extend rather than shorten lifespan. I will discuss the surprising mechanisms that account for stress-induced longevity and the degree to which they may be conserved between flies and mammals.

Audience: Members of the University only