Infectious Diseases & Microbiology
Professor Derrick Crook developed a research programme in translating whole genome sequencing of pathogens and linkage of patient data contained in hospital databases. By linking whole genomic typing of pathogens with this patient data, his research is leading to more rapid and effective diagnosis, management and tracking of common infections such as MRSA (methicillin-resistant Staphylococcus aureus), Clostridium difficile, Tuberculosis and Norovirus.
From Bench to Bedside
Ultimately, medical research must translate into improved treatments for patients. At the Nuffield Department of Medicine, our researchers collaborate to develop better health care, improved quality of life, and enhanced preventative measures for all patients. Our findings in the laboratory are translated into changes in clinical practice, from bench to bedside.
Tackling and tracking TB through DNA analysis
Find out how a multidisciplinary team of scientists came to create England's new way to identify how to fight and track TB outbreaks using DNA analysis.
Interviewees in order of appearance:
- Dr Nicola Fawcett: Clinical Research Fellow and a Doctor in Acute and General Medicine; Nicola studies antibiotic prescribing and the effects on antimicrobial resistance in the gut bacteria.
- Dr Jessica Hedge: Population Geneticist; Jessica studies how DNA analysis can be used to understand how bacteria evolve and develop drug resistance.
- Dr Timothy Walker: Academic Clinical Lecturer and Doctor in Microbiology/Infectious Diseases; Timothy studies how DNA analysis can be used to predict drug resistance, understand transmission of infections, and inform patient care.
- Professor Derrick Crook: Research Group Lead and Direct of the National Infection Service at Public Health England; Derrick has led the group in pioneering the use of DNA analysis from laboratory to patient care.
- Dr Dilrini de Silva: Bioinformatician; Dilrini designs and performs complex, large scale computational analyses of bacterial DNA to provide information on drug resistance and transmission of infections.
Read more about the study (as well as the original paper) on the Modernising Medical Microbiology website.