CD81, a member of the tetraspanin integral membrane protein family, has been identified as an essential receptor for HCV (hepatitis C virus). The present review highlights recent published data on the role that CD81 plays in HCV entry, including the importance of actin-dependent lateral diffusion of CD81 within the cell membrane, CD81 endocytosis and the CD81–Claudin-1 receptor complex in HCV internalization. Additional functions for CD81 in the viral life cycle and the role of HCV–CD81 interactions in HCV-induced B-cell and CNS (central nervous system) abnormalities are discussed.
Journal article
Portland Press Ltd.
2011-04-01T00:00:00+00:00
39
532 - 536
4