ntifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis.

O'Connor L., Van Anh D., Chau TTH., Chau NVV., Huong LNP., Wolbers M., Day JN.

We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance.

DOI

10.1093/cid/ciaa1544

Type

Journal article

Publication Date

2021-10-01T00:00:00+00:00

Volume

73

Pages

e2338 - e2341

Addresses

Guy's and St Thomas' NHS Trust, United Kingdom.

Keywords

Humans, Meningitis, Cryptococcal, Acquired Immunodeficiency Syndrome, Fluconazole, Flucytosine, Antifungal Agents

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