Central Nervous System Involvement by Novel Clade 2.3.2.1e H5N1 Avian Influenza Virus in a Pediatric Patient

Nguyen PNT., Hung NT., Minh NNQ., Hong NTT., Huong NTT., Hiep CM., Nhan LNT., Dinh TV., Quy DT., Thuc TT., Nhut TM., Ny NTH., Nguyet LA., Nhu LNT., Han DDK., Truc THC., Uyen LTT., Ngoc NM., Thao TNP., Tam TTT., Mak ST-M., Siegers JY., Maurer-Stroh S., Dung NT., Karlsson EA., Thwaites G., Tan CW., Chau NVV., Tan LV., Anh NT., Thu Hong NT., Chau Truc TH., Han Ny NT., Kim Han DD., Thanh LK., Nguyet LA., Thuy CT., Truc Nhu LN., Thanh TT., Yen LM., Ty Hang VT., Long PN., Kieu PT., Hoang VT., Thao NT., Chambers M., Thanh VD., Long PN., van Doorn HR., Tung TS., Thwaites CL., Thwaites G., Wang L-F., Lim BL., Hamers RL., Shankar A., Suwarti S., Tayipto T., Simarmata E., Dien R., Mongkolsapaya J., Dejnirattisai W., Chantima W., Chantratita N., Poolchanuan P., Tiacharoen V., Dulsuk A., Iamsirithaworn S., Day N., Cheah PY., Poomchaichote T., Boonthaworn K., Screaton G., Dijokaite-Guraliuc A., Das R., Liu C., Supasa P., Selvaraj M., Dunachie SJ., Klenerman P., Jones EY., Stuart DI., Kronsteiner-Dobramysl B., Zewdie M., Abraham P., Hill J., My Ngoc N., Grifoni A., Sette A., Yap WC., Tan CW., Van Tan L.

Abstract Novel clade 2.3.2.1e A(H5N1) virus was detected in cerebrospinal fluid but not in respiratory, rectal swab, or blood samples of an 8-year-old boy presenting with meningoencephalitis without respiratory symptoms. Cerebrospinal fluid A(H5N1) hemagglutinin–specific antibody levels were higher than those of sera. Clinicians should be aware of emerging clade 2.3.2.1e A(H5N1)–associated meningoencephalitis.

DOI

10.1093/ofid/ofag283

Type

Journal article

Publisher

Oxford University Press (OUP)

Publication Date

2026-04-28T00:00:00+00:00

Volume

13

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