Henipaviruses, particularly the species Nipah (NiV) and Hendra (HeV), are emerging viral threats with potential to cause a public health emergency of international concern due to their high virulence and absence of approved preventative and therapeutical countermeasures. Consequently, research of NiV and HeV is restricted to high-containment laboratories and relies heavily on in vitro models. Despite NiV and HeV initial characterisation >25 years ago, significant gaps remain in the knowledge of the host-pathogen interactions, which are an important research focus for design of therapeutics and supportive care modalities. This review summarises current knowledge in the host-pathogen interactions of henipaviruses and critically assesses the current and emerging in vivo and in vitro models for henipavirus research.
Journal article
2026-01-01T00:00:00+00:00
123
Pandemic Sciences Institute and Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK. Electronic address: jakub.hantabal@ndm.ox.ac.uk.
Animals, Humans, Henipavirus, Hendra Virus, Nipah Virus, Henipavirus Infections, Host-Pathogen Interactions