Miles Carroll
Research groups
Miles Carroll
HOST-PATHOGEN INTERACTIONS OF HIGH CONSEQUENCE EMERGING VIRUSES
Our work centres around high consequence emerging viral infections. Currently, our focus is on Ebola, Lassa fever and SARS-CoV-2. We are interested in host-pathogen interactions, development of anti-virals and recently we have been looking at the IgG response following SARS-CoV-2 infection and/or vaccination in humans and animal models. To further support this work we are using a live virus neutralisation, multiplex immunoassays and novel ACE2 inhibition assay to inform on the ability of serum to neutralise SARS-CoV-2 variants of concern (VOC). We are also interested in the innate response to viral infection, particularly activation and/or evasion of the complement system
Recent publications
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Immunogenicity of COVID-19 vaccines in patients with follicular lymphoma receiving frontline chemoimmunotherapy.
Journal article
Lim YJ. et al, (2024), British journal of haematology, 205, 440 - 451
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Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 controlled human infection study
Journal article
Jackson S. et al, (2024), The Lancet Microbe, 5, 655 - 668
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Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial.
Journal article
Goodyear CS. et al, (2024), The Lancet. Rheumatology, 6, e339 - e351
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Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Journal article
Cornish K. et al, (2024), Open biology, 14
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Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea.
Journal article
Akoi Boré J. et al, (2024), Nature communications, 15