ABSTRACT Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae . We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly- N -acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
Journal article
American Society for Microbiology
2014-09-01T00:00:00+00:00
88
10244 - 10251
7