Contact information

Website
MRC Translational Immune Discovery Unit

Address
MRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headington OX3 9DS

Images from our research

Group members

Dr Jeongmin Woo

Dr Neda Hasan

Mr Chaitanya Vuppusetty (Lab manager)

Dr Praveen Weeratunga

Dr Harry Tian Hu

Dr Vishal Nathwani

Dr Sabrina Zulfikar

Dr Leila Baghaarabani

Dr Yaron Ben-Ami

Affiliates

Prof Daisy Yuejuan Zheng

Dr Andrew Achaiah

Ling-Pei Ho

DPhil, FRCP, MD

Professor of Respiratory Immunology

Consultant in Respiratory Medicine
NIHR Oxford BRC Respiratory Theme Lead
UK NIHR Respiratory-Translational Research Collaboration

Immune mechanisms in lung fibrosis

See our Spotlight video - https://youtu.be/Dj0uNQgA1Fs

My research group studies how immunological responses impact on mechanisms of lung injury, regeneration and repair. Our projects are divided into mechanistic and translational studies. We have two aims – (1) to understand the contribution of immune cells to chronic progressive lung fibrosis and alveolar regneration (2) to use this knowledge to bring new treatment and improved management to patients with fibrotic lung diseases,focusing on idiopathic pulmonary fibrosis (IPF) and fibrotic sarcoidosis.

We focus on both the lung tissue and blood in human studies, and longitudinal murine studies. In the lungs, we have developed methods (with mathematicians) to map out the spatial organisation of immune cells using mathematical tools, single cell imaging mass cytometry and single cell transcriptomics.

Note: for Clinical Respiratory Specialist inquiries, Prof Ho's address is

Interstitial Lung Disease Service

Oxford Center for Respiratory Medicine

Churchill Hospital, Oxford OX3 7LJ

Key publications

Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis

Weeratunga P. et al, (2025), Nature Communications, 16

Immune mechanisms of granuloma formation in sarcoidosis and tuberculosis

Weeratunga P. et al, (2024), Journal of Clinical Investigation, 134

Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs

Weeratunga P. et al, (2023), Nature Communications, 14

Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

Cross AR. et al, (2023), JCI Insight, 8

Immune mechanisms in fibrotic pulmonary sarcoidosis

Weeratunga P. et al, (2022), European Respiratory Review, 31, 220178 - 220178

Increased monocyte level is a risk factor for radiological progression in patients with early fibrotic interstitial lung abnormality

Achaiah A. et al, (2022), ERJ Open Research, 8, 00226 - 2022

COVID-19 therapeutics: Challenges and directions for the future

Robinson PC. et al, (2022), Proceedings of the National Academy of Sciences, 119

blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Ahern DJ. et al, (2022), Cell, 185, 916 - 938.e58

Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype

Fraser E. et al, (2021), Frontiers in Immunology, 12

Recent publications

Spatial fibroblast niches define Crohn’s fistulae

McGregor C. et al, (2026), Nature, 649, 703 - 712

Correction: Spatial fibroblast niches define Crohn’s fistulae

McGregor C. et al, (2025), Nature, 648, E7 - E7

Topology across scales on heterogeneous cell data

Torras-Pérez M. et al, (2025), PLOS Computational Biology, 21, e1013460 - e1013460

Clinical and cost-effectiveness of diverse posthospitalisation pathways for COVID-19: a UK evaluation using the PHOSP-COVID cohort

Briggs AH. et al, (2025), BMJ Open Respiratory Research, 12, e003224 - e003224

Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis

Weeratunga P. et al, (2025), Nature Communications, 16

Readability and complexity of written information presented to hospitalised patients for trial consent during the COVID-19 pandemic in the UK: a retrospective document analysis

Gourlay E. et al, (2025), BMJ Open, 15, e089447 - e089447

Idiopathic pulmonary fibrosis in the UK: findings from the British Thoracic Society UK Idiopathic Pulmonary Fibrosis Registry

Fahim A. et al, (2025), BMJ Open Respiratory Research, 12, e002773 - e002773

Incidence of diabetes mellitus following hospitalisation for COVID ‐19 in the United Kingdom: A prospective observational study

Tyrer F. et al, (2025), Diabetes, Obesity and Metabolism, 27, 767 - 776

Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID‐19

Devine K. et al, (2024), Clinical Endocrinology, 100, 317 - 327

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Liew F. et al, (2024), Nature Immunology, 25, 607 - 621

Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study

Elneima O. et al, (2024), International Journal of Epidemiology, 53

Immune mechanisms of granuloma formation in sarcoidosis and tuberculosis

Weeratunga P. et al, (2024), Journal of Clinical Investigation, 134

Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury

Taquet M. et al, (2023), Brain Communications, 6

Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs

Weeratunga P. et al, (2023), Nature Communications, 14

Long COVID research: an update from the PHOSP-COVID Scientific Summit

Brightling CE. et al, (2023), The Lancet Respiratory Medicine, 11, e93 - e94

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Raman B. et al, (2023), The Lancet Respiratory Medicine, 11, 1003 - 1019

cute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization

Taquet M. et al, (2023), Nature Medicine, 29, 2498 - 2508

Implementable Deep Learning for Multi‐sequence Proton MRI Lung Segmentation: A Multi‐center, Multi‐vendor, and Multi‐disease Study

Astley JR. et al, (2023), Journal of Magnetic Resonance Imaging, 58, 1030 - 1044

Neutrophil levels correlate with quantitative extent and progression of fibrosis in IPF: results of a single-centre cohort study

Achaiah A. et al, (2023), BMJ Open Respiratory Research, 10, e001801 - e001801

andomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2

Wilkinson T. et al, (2023), ERJ Open Research, 9, 00249 - 2023

Genetic and geographic influence on phenotypic variation in European sarcoidosis patients

Freitag-Wolf S. et al, (2023), Frontiers in Medicine, 10

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study

Jackson C. et al, (2023), The Lancet Respiratory Medicine, 11, 673 - 684

Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis

Dawson C. et al, (2023), BMJ Open Respiratory Research, 10, e001647 - e001647

Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

Zheng B. et al, (2023), The Lancet Regional Health - Europe, 29, 100635 - 100635

Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

Elneima O. et al, (2023)

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

Stewart I. et al, (2023), American Journal of Respiratory and Critical Care Medicine, 207, 693 - 703

Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Absence in the Lungs of Fatal COVID-19: A Retrospective Histopathology Cohort Study

Melero I. et al, (2023), SSRN Electronic Journal

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

McAuley HJC. et al, (2023), eClinicalMedicine, 57, 101896 - 101896

Correction: The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium

Daynes E. et al, (2023), Trials, 24

Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial

Khoo SH. et al, (2023), The Lancet Infectious Diseases, 23, 183 - 195

The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium

Daynes E. et al, (2023), Trials, 24

Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

Cross AR. et al, (2023), JCI Insight, 8

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Liew F. et al, (2023), eBioMedicine, 87, 104402 - 104402

Cytokine Storm in Acute Viral Respiratory Injury: Role of Qing-Fei-Pai-Du Decoction in Inhibiting the Infiltration of Neutrophils and Macrophages through TAK1/IKK/NF-κB Pathway

Ye X-L. et al, (2023), The American Journal of Chinese Medicine, 51, 1153 - 1188

Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19

Daines L. et al, (2023), ERJ Open Research, 9, 00274 - 2022

Immune mechanisms in fibrotic pulmonary sarcoidosis

Weeratunga P. et al, (2022), European Respiratory Review, 31, 220178 - 220178

Unbiased single cell spatial analysis localises inflammatory clusters of immature neutrophils-CD8 T cells to alveolar progenitor cells in fatal COVID-19 lungs

Weeratunga P. et al, (2022)

The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study

Jackson C. et al, (2022)

Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study

Plekhanova T. et al, (2022), International Journal of Behavioral Nutrition and Physical Activity, 19

Management of Sarcoidosis: When to Treat, How to Treat and for How Long?

Fraser E. et al, (2022), Current Pulmonology Reports, 11, 151 - 159

P27 Blood neutrophil levels in IPF patients are significantly associated with quantitative radiological progression of fibrosis

Achaiah A. et al, (2022), ‘Scar Wars’ – The pot pourri of ILD, A94.2 - A95

Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19

Melero I. et al, (2022), CHEST, 162, 1006 - 1016

Phase II study of neoadjuvant axitinib for reducing the extent of venous tumour thrombus in clear cell renal cell cancer with venous invasion (NAXIVA)

Stewart GD. et al, (2022), British Journal of Cancer, 127, 1051 - 1060

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Kotanidis CP. et al, (2022), The Lancet Digital Health, 4, e705 - e716

Nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Liew F. et al, (2022)

Patient perspective on antifibrotic monitoring - impact on management at a single UK prescribing centre

Hussain S. et al, (2022), 09.03 - Nurses, 2877 - 2877

Patient perceived facilitators to greater self-management using home spirometry

Parsons K. et al, (2022), 01.04 - M-Health/e-health, 2864 - 2864

Blood neutrophil levels in IPF patients are significantly associated with quantitative radiological progression

Achaiah A. et al, (2022), 12.01 - Idiopathic interstitial pneumonias, 4479 - 4479

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Evans RA. et al, (2022), The Lancet Respiratory Medicine, 10, 761 - 775

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome

Robinson KS. et al, (2022), Science, 377, 328 - 335

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Houchen-Wolloff L. et al, (2022), Thorax, 77, 717 - 720

Increased monocyte level is a risk factor for radiological progression in patients with early fibrotic interstitial lung abnormality

Achaiah A. et al, (2022), ERJ Open Research, 8, 00226 - 2022

Big data and long COVID

The Lancet Digital Health ., (2022), The Lancet Digital Health, 4, e477 - e477

Early-phase clinical trials in a pandemic: learning from the response to COVID-19

Horsley A. et al, (2022), The Lancet Respiratory Medicine, 10, 625 - 627

Neutrophil lymphocyte ratio as an indicator for disease progression in Idiopathic Pulmonary Fibrosis

Achaiah A. et al, (2022), BMJ Open Respiratory Research, 9, e001202 - e001202

Large scale clinical trials: lessons from the COVID-19 pandemic

Horsley AR. et al, (2022), BMJ Open Respiratory Research, 9, e001226 - e001226

Blood Leukocyte Levels Are Associated with Radiological Progression of Early Fibrotic ILA Within Five Years

Achaiah A. et al, (2022), D92. TRYING TO NIP IT IN THE BUD: ADVANCES IN UNDERSTANDING INTERSTITIAL LUNG ABNORMALITIES, A5272 - A5272

COVID-19 therapeutics: Challenges and directions for the future

Robinson PC. et al, (2022), Proceedings of the National Academy of Sciences, 119

Interstitial lung damage following COVID-19 hospitalisation: an interim analysis of the UKILD Post-COVID study

Stewart I. et al, (2022)

Divergent trajectories of antiviral memory after SARS-CoV-2 infection

Tomic A. et al, (2022), Nature Communications, 13

blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Ahern DJ. et al, (2022), Cell, 185, 916 - 938.e58

Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial

Fisher BA. et al, (2022), The Lancet Respiratory Medicine, 10, 255 - 266

Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a prospective, multicentre study

(2022)

n immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Peng Y. et al, (2022), Nature Immunology, 23, 50 - 61

Constructing custom-made radiotranscriptomic signatures from CT angiograms: an application in COVID-19 vascular inflammation

Kotanidis CP. et al, (2022), EUROPEAN HEART JOURNAL, 43, 198 - 198

Clinical characteristics with inflammation profiling of Long-COVID and association with one-year recovery following hospitalisation in the UK: a prospective observational study

(2021)

Symptom Persistence Despite Improvement in Cardiopulmonary Health – Insights from longitudinal CMR, CPET and lung function testing post-COVID-19

Cassar MP. et al, (2021), eClinicalMedicine, 41, 101159 - 101159

Monocyte and neutrophil levels are potentially linked to progression to IPF for patients with indeterminate UIP CT pattern

Achaiah A. et al, (2021), BMJ Open Respiratory Research, 8, e000899 - e000899

P3 Progression of early fibrotic ILA to established interstitial lung disease and mortality: observations from a regional centre

Achaiah A. et al, (2021), ILD: how big is the problem? How can you spot it and how should you monitor it?, A68.1 - A68

Improved COVID-19 outcomes in a large non-invasive respiratory support cohort despite emergence of the alpha variant

Turnbull CD. et al, (2021), BMJ Open Respiratory Research, 8, e001044 - e001044

Hyperpolarized 129Xe MRI Abnormalities in Dyspneic Patients 3 Months after COVID-19 Pneumonia: Preliminary Results

Grist JT. et al, (2021), Radiology, 301, E353 - E360

Late Breaking Abstract - Breathlessness post COVID-19 despite improvement in cardiopulmonary health

Cassar MP. et al, (2021), Clinical problems, PA3890 - PA3890

Blood leukocyte levels as potential prognostic markers in IPF

Achaiah A. et al, (2021), Idiopathic interstitial pneumonias, PA388 - PA388

Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)

Wild JM. et al, (2021), BMJ Open Respiratory Research, 8, e001049 - e001049

Monocyte and neutrophil levels are potentially linked to progression to IPF for patients with indeterminate UIP CT pattern

Achaiah A. et al, (2021)

Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Skelly DT. et al, (2021), Nature Communications, 12

Symptom Persistence Despite Improvement in Cardiopulmonary Health – Insights from longitudinal CMR, CPET and lung function testing post-COVID-19

Cassar MP. et al, (2021)

Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern.

Skelly DT. et al, (2021), Nature communications, 12

Immunodominant NP105-113-B*0702 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Dong T. et al, (2021)

lveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis

Shi T. et al, (2021), Journal of Leukocyte Biology, 110, 107 - 114

Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

Cross AR. et al, (2021)

Namilumab or infliximab compared to standard of care in hospitalised patients with COVID-19 (CATALYST): a phase 2 randomised adaptive trial

Fisher BA. et al, (2021)

blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Ahern DJ. et al, (2021)

P058 Persistence of neutrophil abnormalities in COVID-19 convalescence

Williams TO. et al, (2021), Rheumatology, 60

Physical, cognitive and mental health impacts of COVID-19 following hospitalisation – a multi-centre prospective cohort study

Evans RA. et al, (2021)

Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype

Fraser E. et al, (2021), Frontiers in Immunology, 12

S79 Prevalence of the indeterminate for UIP CT feature and potential link between monocyte and neutrophil levels and progression to IPF – a single centre analysis

Achaiah A. et al, (2021), Basic science in ILD: what drives progression?, A48.3 - A49

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

Monk PD. et al, (2021), The Lancet Respiratory Medicine, 9, 196 - 206

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

Raman B. et al, (2021), EClinicalMedicine, 31, 100683 - 100683

BTS Clinical Statement on pulmonary sarcoidosis

Thillai M. et al, (2021), Thorax, 76, 4 - 20

Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study

Drake TM. et al, (2020), American Journal of Respiratory and Critical Care Medicine, 202, 1656 - 1665

CCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial

Wilkinson T. et al, (2020), Trials, 21

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Peng Y. et al, (2020), Nature Immunology, 21, 1336 - 1345

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

Raman B. et al, (2020)

Recovery of monocyte exhaustion is associated with resolution of lung injury in COVID-19 convalescence

Scott NA. et al, (2020)

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Mann ER. et al, (2020), Science Immunology, 5

Evolution of the ‘Indeterminate UIP’ HRCT pattern; a cohort snapshot

Achaiah A. et al, (2020), Idiopathic interstitial pneumonias, 786 - 786

Immunologically 'supercharged' monocytes as drivers of chronic fibrosis in idiopathic pulmonary fibrosis

Fraser E. et al, (2020), Idiopathic interstitial pneumonias, 819 - 819

Eligibility for anti-fibrotic therapy of patients in British Thoracic Society (BTS) UK IPF Registry varies according to the reference values used to calculate FVC

Molyneaux P. et al, (2020), Idiopathic interstitial pneumonias, 1798 - 1798

Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience

Hallifax RJ. et al, (2020), BMJ Open Respiratory Research, 7, e000678 - e000678

Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.

Drake TM. et al, (2020)

Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

Zhao Y. et al, (2020), JCI Insight, 5

Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis

Mann ER. et al, (2020)

Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients

Peng Y. et al, (2020)

Readily accessible CT scoring method to quantify fibrosis in IPF

Fraser E. et al, (2020), BMJ Open Respiratory Research, 7, e000584 - e000584

Longitudinal Profiling of Cytokines and Chemokines in COVID-19 Reveals Inhibitory Mediators IL-1Ra and IL-10 Are Associated with Disease Severity While Elevated RANTES Is an Early Predictor of Mild Disease

Zhao Y. et al, (2020), SSRN Electronic Journal

Type-1 IFN primed monocytes in pathogenesis of idiopathic pulmonary fibrosis

Fraser E. et al, (2020)

Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza

Jha A. et al, (2019), European Respiratory Journal, 54, 1900949 - 1900949

How the Respiratory Epithelium Senses and Reacts to Influenza Virus

Benam KH. et al, (2019), American Journal of Respiratory Cell and Molecular Biology, 60, 259 - 268

Sarcoidosis in the UK: insights from British Thoracic Society registry data

Thillai M. et al, (2019), BMJ Open Respiratory Research, 6, e000357 - e000357

S75 A readily accessible CT-based score to measure amount of fibrosis in IPF

Fraser E. et al, (2018), Novel imaging and outcome measures in ILD, A46.1 - A46

Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK

Watson RA. et al, (2018), British Journal of Cancer, 119, 1044 - 1051

The role of respiratory epithelium in host defence against influenza virus infection

Denney L. and Ho L-P., (2018), Biomedical Journal, 41, 218 - 233

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Dunning J. et al, (2018), Nature Immunology, 19, 625 - 635

Clinical Genetics in Interstitial Lung Disease

Newton CA. et al, (2018), Frontiers in Medicine, 5

Phenotypes of organ involvement in sarcoidosis

Schupp JC. et al, (2018), European Respiratory Journal, 51, 1700991 - 1700991

Blood Monocyte Levels Correlate with Fibrotic Burden in IPF Patients and Show Pro-Fibrogenic Characteristics

Fraser E. et al, (2018), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 197

S77 Transcriptomic studies reveal monocyte-related genes as major contributor to disease activity in pulmonary sarcoidosis

Kendrick Y. et al, (2017), Mechanistic insights into interstitial lung disease, A48.2 - A49

Pulmonary sarcoidosis

Moller DR. and Ho L-P., (2017), 257 - 270

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza

Cole SL. et al, (2017), JCI Insight, 2

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.

Cole SL. et al, (2017), JCI insight, 2

Contribution of innate immune cells to pathogenesis of severe influenza virus infection

Cole SL. and Ho L-P., (2017), Clinical Science, 131, 269 - 283

CTAS: a CT score to quantify disease activity in pulmonary sarcoidosis

Benamore R. et al, (2016), Thorax, 71, 1161 - 1163

P284 Identifying patients at risk of acute exacerbation of ipf using the cpi score

Fraser E. et al, (2016), Thorax, 71, A243.1 - A243

S50 Monocytes from IPF patients show pre-conditioned pro-repair features

Fraser E. et al, (2016), Thorax, 71, A30.2 - A31

S78 Lymphopaenia and increased ace levels stratify sarcoidosis patients to underlying increase in IFN-γ + lymphocyte and TNF-α+ monocytes respectively

Kendrick YK. et al, (2016), Thorax, 71, A45.2 - A45

P39 CTAS – a ct score to quantify disease activity in pulmonary sarcoidosis

Kendrick YK. et al, (2016), Thorax, 71, A103.2 - A103

S101 Single centre experience of switching patients with idiopathic pulmonary fibrosis from pirfenidone to nintedanib

Rathnapala A. et al, (2016), Thorax, 71, A60.1 - A60

P175 Single centre experience of the real-life impact of pirfenidone on lung function in patients with idiopathic pulmonary fibrosis

Rathnapala A. et al, (2016), Thorax, 71, A179.1 - A179

P170 Single centre experience on idiopathic pulmonary fibrosis patient tolerance of pirfenidone; impact on nurse-led ILD helpline usage

Rathnapala A. et al, (2016), Thorax, 71, A176.1 - A176

MAIT cells are activated during human viral infections

van Wilgenburg B. et al, (2016), Nature Communications, 7

P25 Distinct Pro-inflammatory Gene Expression Profile In Monocytes From Sarcoidosis Patients With Active Disease

Crawshaw A. et al, (2014), Thorax, 69, A88 - A88

P24 Vitamin D Levels Are Low In Sarcoidosis And Contribute To Abnormal Monocyte Activity

Crawshaw A. et al, (2014), Thorax, 69, A88 - A88

ccumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom

Elderfield RA. et al, (2014), Journal of Virology, 88, 13269 - 13283

72-year-old woman with a persistent cough and abnormal chest X-ray

Corcoran JP. et al, (2014), British Journal of Hospital Medicine, 75, 652 - 653

bnormalities in iNKT cells are associated with impaired ability of monocytes to produce IL‐10 and suppress T‐cell proliferation in sarcoidosis

Crawshaw A. et al, (2014), European Journal of Immunology, 44, 2165 - 2174

Involvement of the 4-1BB/4-1BBL Pathway in Control of Monocyte Numbers by Invariant NKT Cells

Cole SL. et al, (2014), The Journal of Immunology, 192, 3898 - 3907

streamlined implementation of the glutamine synthetase-based protein expression system

Knox R. et al, (2013), BMC Biotechnology, 13

Lumps, bumps and diagnostic stumps

Ashdown HF. et al, (2013), British Journal of General Practice, 63, 663 - 664

Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers

Bloom CI. et al, (2013), PLoS ONE, 8, e70630 - e70630

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

Martinez FO. et al, (2013), Blood, 121, e57 - e69

Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

Zhang Y-H. et al, (2013), Nature Communications, 4

Combination Score Of Raised Sace, Lymphopenia And Hypergammaglobulinemia Correlates With Active Disease On Thoracic CT Scan Of Patients With Pulmonary Sarcoidosis

Kendrick Y. et al, (2013), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187

High Levels of Virus-Specific CD4 + T Cells Predict Severe Pandemic Influenza A Virus Infection

Zhao Y. et al, (2012), American Journal of Respiratory and Critical Care Medicine, 186, 1292 - 1297

S96 A combination score of raised sACE, lymphopenia and hypergammaglobulinaemia correlates with active disease on thoracic CT scan of patients with pulmonary sarcoidosis

Kendrick YR. et al, (2012), Thorax, 67, A47.2 - A48

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

Wegmann F. et al, (2012), Nature Biotechnology, 30, 883 - 888

ctivation of Invariant NKT Cells in Early Phase of Experimental Autoimmune Encephalomyelitis Results in Differentiation of Ly6Chi Inflammatory Monocyte to M2 Macrophages and Improved Outcome

Denney L. et al, (2012), The Journal of Immunology, 189, 551 - 557

IFITM3 restricts the morbidity and mortality associated with influenza

Everitt AR. et al, (2012), Nature, 484, 519 - 523

IFITM3 restricts the morbidity and mortality associated with influenza

Everitt AR. et al, (2012), NATURE, 484, 519 - U146

S109 Contribution of aberrant monocyte-natural killer T (NKT) cell axis to immune-pathology in sarcoidosis

Crawshaw AP. et al, (2011), Thorax, 66, A50 - A51

Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection

Kok WL. et al, (2011), Journal of Leukocyte Biology, 91, 357 - 368

Hepcidin regulation by innate immune and infectious stimuli

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Hepcidin regulation by innate immune and infectious stimuli

Armitage AE. et al, (2011), Blood, 118, 4129 - 4139

lternative spliced CD1d transcripts in human bronchial epithelial cells

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lternative Spliced CD1D Transcripts in Human Bronchial Epithelial Cells

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Evidence for association between sarcoidosis and pulmonary embolism from 35-year record linkage study

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Parallel Session 8: Molecular and clinical interfaces of invariant natural killer T cells (iNKT)

Denney L. et al, (2011), IMMUNOLOGY, 135, 41 - 41

Exosomes in lungs of patients with sarcoidosis: a contributor to immune pathogenesis or just another by-product of heightened immune activity?

Ho L-P., (2010), Thorax, 65, 947 - 948

Reduction of natural killer but not effector CD8 t lymphoyctes in three consecutive cases of severe/lethal H1N1/09 influenza a virus infection

Denney L. et al, (2010), PLoS ONE, 5

Gene Set Analysis of Lung Samples Provides Insight into Pathogenesis of Progressive, Fibrotic Pulmonary Sarcoidosis

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Reduction of Natural Killer but Not Effector CD8 T Lymphoyctes in Three Consecutive Cases of Severe/Lethal H1N1/09 Influenza A Virus Infection

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Potent adaptive immune responses induced against HIV-1 gp140 and influenza virus HA by a polyanionic carbomer

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Exosomes in lungs of patients with sarcoidosis: A contributor to immune pathogenesis or just another by-product of heightened immune activity?

Ho LP., (2010), Thorax, 65, 947 - 948

Functional analysis of dendritic cell–T cell interaction in sarcoidosis

Kulakova N. et al, (2009), Clinical and Experimental Immunology, 159, 82 - 86

GENE SET ANALYSIS OF LUNG SAMPLES FROM PROGRESSIVE, FIBROTIC PULMONARY SARCOIDOSIS SHOWS A PATTERN SIMILAR TO HYPERSENSITIVITY PNEUMONITIS

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EVIDENCE FOR ASSOCIATION BETWEEN SARCOIDOSIS AND PULMONARY EMBOLISM FROM 30-YEAR RECORD LINKAGE STUDY

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ctivation of invariant NKT cells enhances the innate immune response and improves the disease course in influenza A virus infection

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Invariant NKT cells are required for a proportionate innate immune response to highly pathogenic influenza A virus infection

Kok WL. et al, (2008), IMMUNOLOGY, 125, 85 - 85

Reduced Interleukin-18 Levels in BAL Specimens From Patients With Asthma Compared to Patients With Sarcoidosis and Healthy Control Subjects

Ho L-P. et al, (2002), Chest, 121, 1421 - 1426

Correlation between nasal potential difference measurements, genotype and clinical condition in patients with cystic fibrosis

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Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

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Immune mechanisms in lung fibrosis

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