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News

The latest news, research updates and announcements from the Nuffield Department of Medicine.

For media enquiries, background information on any of our research, or to arrange interviews with relevant scientists please contact Marin Hirschfeld, NDM Head of Communications. We also have photos and videos of our work available for B-roll purposes.

What's new

Ludwig Oxford researchers identify a crucial factor for neurodevelopment

Publications & research news

Work from Professor Yang Shi’s research team both in the Boston Children’s Hospital, Harvard Medical School and Oxford has shed new light on KDM5C mutation-associated intellectual disability and advanced the general understanding of memory and anxiety formation with the identification of Wnt functioning in a transient nature to impact long-lasting cognitive function.

Study finds high number of persistent COVID-19 infections

Publications & research news

A new study led by the Big Data Institute at NDM has found persistent COVID-19 infections are surprisingly common, with around one to three in every 100 infections lasting a month or longer.

Determining the origins of falsified antimalarials using isotope mass spectrometry

Publications & research news

In a recent study, the Medicine Quality Group at the Infectious Diseases Data Observatory (IDDO) and Mahidol Oxford Tropical Medicine Research Unit (MORU) at NDM used stable isotope mass spectrometry to estimate where falsified antimalarials and their components come from.

Repurposed tests can detect falsified vaccines

Publications & research news

Researchers have found that widely available rapid diagnostic tests (RDTs), typically used for common infections, can be repurposed to detect substandard and falsified (SF) vaccines, a significant but overlooked issue in global public health. Preliminary data suggests RDTs could be utilized by international organizations and regulators to screen vaccine supply chains for counterfeit products. This innovative approach addresses the urgent need for affordable tools to combat the threat of SF vaccines.

Rising antimicrobial resistance in enteric fever across 75 countries

Publications & research news

Recent findings by the Global Research on Antimicrobial Resistance Project at NDM's Centre for Tropical Medicine and Global Health revealed the resistance patterns for a priority pathogen--also known as typhoid fever--with high mortality and morbidity in resource-constrained settings.

Study provides framework for optimising the design of antibody therapeutics

Publications & research news

New research by NDM, the Radcliffe Department of Medicine, the MRC Translational Immune Discovery Unit and University of Cambridge research groups, has uncovered how antibodies trigger immune receptors in T cells. This breakthrough provides an improved framework for designing therapeutic antibodies, which could be used in new and better therapies for cancer and autoimmune diseases.

Study reveals a surge in poor-quality medical products during pandemic

Publications & research news

A recent study by the Medicine Quality Research Group found that during the pandemic there was a surge in low-quality COVID-19 medical products globally, including substandard and counterfeit medicines, diagnostics, PPE, sanitisers, and vaccines.

OUCRU develops a novel diagnostic tool for Tuberculous Meningitis

Publications & research news

A team of researchers at NDM’s Oxford University Clinical Research Unit (OUCRU) has pioneered a novel, microbiological assay-independent diagnostic model for adult Tuberculous Meningitis, leveraging Bayesian latent class analysis to improve the accuracy of diagnoses. This innovative approach, promises to enhance the detection and treatment of one of the most severe forms of tuberculosis (TB).

ASAP Discovery Consortium wins 2023 FASEB Dataworks prize

Awards News

The AI-driven Structure-enabled Antiviral Platform (ASAP) has won an Exemplary Achievement Award from the Federation of American Societies for Experimental Biology (FASEB) and the National Institutes of Health (NIH). The prize recognises data practices in biological and biomedical research labs during the active phase of research.

New teaching collaboration with Brazilian universities

News

The University of Oxford has entered into an agreement with three Brazilian universities, to contribute to the delivery of an undergraduate course in ‘Translational Science’, starting in 2024. The course will teach the full journey of a product ‘from bench to bedside’ as part of any science degree to prepare the next generation of researchers for the translation of their laboratory discoveries into patient care and prevention.

R21 malaria vaccine phase III trial confirms high efficacy and safety

Publications & research news

The phase III trial data results of the R21/Matrix-M vaccine, developed by the Jenner Institute and the Serum Institute of India have confirmed high efficacy and supported regulatory approvals and licensure in several African countries.

AI-based method provides insights for predicting colorectal cancer outcomes

Publications & research news

The largest multiparameter immunoprofiling study in cancer to date has suggested an underappreciated role of a subset of immune cells in determining the risk of bowel cancer relapse after surgery.

Study uncovers how the Hepatitis B virus adapts

Publications & research news

A new hepatitis B study reveals how viruses adapt to low-oxygen environments, such as those found deep within the liver, opening up possible new therapeutic targets for liver pathogens. NDM researchers have identified hypoxia-inducible factors (HIFs) playing an important role in the regulation of editing of viral RNAs in low oxygen conditions.

UK minister meets with Oxford pandemic researchers

News

Researchers at the Jenner Institute, the Oxford Vaccine Group and the Pandemic Sciences Institute hosted the Rt Hon Andrew Mitchell MP, Minister for Development and Africa, to the laboratories and clinics of several of its vaccine development groups.

New system protects patient data through federated learning

Publications & research news

The Big Data Institute along with the collaborators have developed a new, easy-to-use technique for hospitals to contribute to developing artificial intelligence (AI) models, without patient data leaving the hospital’s premises.

Anomaly detection improves real-time dengue surveillance in Thailand

Publications & research news

A recent study by the Mahidol-Oxford Tropical Medicine Research Unit (MORU) at NDM outlined a highly effective method for dengue surveillance. The researchers improved risk detection in real time by combining space-time modelling and anomaly detection. This will help in making dengue prevention more effective not only in Thailand but also in other regions with similar challenges.

Study shows Favipiravir provides no benefit in treating COVID-19

Publications & research news

A recent study by NDM’s Mahidol Oxford Tropical Medicine Research Unit researchers highlighted that there was no difference in the rate of viral clearance between patients given Favipiravir and patients receiving no study drug.

Study highlights importance of ‘junk’ DNA in unlocking diagnosis

Publications & research news

A recent study led by the Centre for Human Genetics at NDM has revealed that areas of the human genome that are routinely overlooked in clinical tests may be the cause of some rare diseases.

New NIHR Oxford Senior Research Fellows named

Awards News

Researchers from a wide range of disciplines have been appointed to be the next cohort of NIHR Oxford Senior Research Fellows - seven mid-career researchers identified as having the potential to become future translational research leaders. The cohort includes Dr Matthias Friedrich from the Translational Gastroenterology Unit in NDM’s Experimental Medicine Division.

Novel inhaled vaccine for tuberculosis to be trialled

News

The Jenner Institute at NDM is conducting a new study using the Bacille Calmette-Guérin (BCG) vaccine, the only vaccine currently licensed against tuberculosis. People who have received the BCG vaccine previously will be given it again to compare whether giving it by inhalation is better at protecting people against tuberculosis than giving it through the skin.